Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells

Francesco Orio, Giovanna Muscogiuri, Stefano Palomba, Bianca Serio, Mariarosaria Sessa, Valentina Giudice, Idalucia Ferrara, Libuse Tauchmanovà, Annamaria Colao, Carmine Selleri

Research output: Contribution to journalArticle

Abstract

Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90-99% of women and 60-90% of men. Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40-50% of transplanted patients, respectively. Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT. Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT.

Original languageEnglish
Article number282147
JournalTheScientificWorldJournal
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Autologous Transplantation
transplantation
Homologous Transplantation
Hematopoietic Stem Cells
Stem cells
Hypothalamus
stem
Transplants
Survivors
Immune system
Thyroid Gland
immune system
steroid
Euthyroid Sick Syndromes
quality of life
risk factor
Grafts
Growth Hormone
hormone
Adrenal Insufficiency

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Orio, F., Muscogiuri, G., Palomba, S., Serio, B., Sessa, M., Giudice, V., ... Selleri, C. (2014). Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells. TheScientificWorldJournal, 2014, [282147]. https://doi.org/10.1155/2014/282147

Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells. / Orio, Francesco; Muscogiuri, Giovanna; Palomba, Stefano; Serio, Bianca; Sessa, Mariarosaria; Giudice, Valentina; Ferrara, Idalucia; Tauchmanovà, Libuse; Colao, Annamaria; Selleri, Carmine.

In: TheScientificWorldJournal, Vol. 2014, 282147, 2014.

Research output: Contribution to journalArticle

Orio, F, Muscogiuri, G, Palomba, S, Serio, B, Sessa, M, Giudice, V, Ferrara, I, Tauchmanovà, L, Colao, A & Selleri, C 2014, 'Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells', TheScientificWorldJournal, vol. 2014, 282147. https://doi.org/10.1155/2014/282147
Orio, Francesco ; Muscogiuri, Giovanna ; Palomba, Stefano ; Serio, Bianca ; Sessa, Mariarosaria ; Giudice, Valentina ; Ferrara, Idalucia ; Tauchmanovà, Libuse ; Colao, Annamaria ; Selleri, Carmine. / Endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells. In: TheScientificWorldJournal. 2014 ; Vol. 2014.
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