Abstract
Endocytosis and recycling are emerging as essential components of the wiring enabling cells to perceive extracellular signals and resolve them in a temporally and spatially controlled fashion, directly influencing not only the duration and intensity of the signaling output, but also its correct location. One process, which requires the precise resolution of spatial information, is actin-based cell motility. This is achieved by coordinating membrane traffic, cell substrate adhesion, and actin remodeling in order to generate propulsive forces responsible for the formation of a diverse set of polarized migratory protrusions, the first steps of cell locomotion. Here, we will discuss how prototypical endocytic molecules control actin dynamics, frequently by linking the core machinery of actin polymerization to the plasma membrane. We will further discuss how endocytosis and recycling ensure spatial restriction of signaling to actin dynamics, thus enabling cells to migrate in response to different extracellular stimuli and in diverse microenvironments adopting diverse motile strategies, which have important implications in relevant physiological and pathological processes, first and foremost cancer cell invasion and dissemination.
| Original language | English |
|---|---|
| Title of host publication | Actin-based Motility: Cellular, Molecular and Physical Aspects |
| Publisher | Springer Netherlands |
| Pages | 59-84 |
| Number of pages | 26 |
| ISBN (Print) | 9789048193011, 9789048193004 |
| DOIs | |
| Publication status | Published - 2010 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Endocytic control of actin-based motility. / Disanza, Andrea; Frittoli, Emanuela; Giuliani, Chiara; Milanesi, Francesca; Palamidessi, Andrea; Troglio, Flavia; Scita, Giorgio.
Actin-based Motility: Cellular, Molecular and Physical Aspects. Springer Netherlands, 2010. p. 59-84.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Endocytic control of actin-based motility
AU - Disanza, Andrea
AU - Frittoli, Emanuela
AU - Giuliani, Chiara
AU - Milanesi, Francesca
AU - Palamidessi, Andrea
AU - Troglio, Flavia
AU - Scita, Giorgio
PY - 2010
Y1 - 2010
N2 - Endocytosis and recycling are emerging as essential components of the wiring enabling cells to perceive extracellular signals and resolve them in a temporally and spatially controlled fashion, directly influencing not only the duration and intensity of the signaling output, but also its correct location. One process, which requires the precise resolution of spatial information, is actin-based cell motility. This is achieved by coordinating membrane traffic, cell substrate adhesion, and actin remodeling in order to generate propulsive forces responsible for the formation of a diverse set of polarized migratory protrusions, the first steps of cell locomotion. Here, we will discuss how prototypical endocytic molecules control actin dynamics, frequently by linking the core machinery of actin polymerization to the plasma membrane. We will further discuss how endocytosis and recycling ensure spatial restriction of signaling to actin dynamics, thus enabling cells to migrate in response to different extracellular stimuli and in diverse microenvironments adopting diverse motile strategies, which have important implications in relevant physiological and pathological processes, first and foremost cancer cell invasion and dissemination.
AB - Endocytosis and recycling are emerging as essential components of the wiring enabling cells to perceive extracellular signals and resolve them in a temporally and spatially controlled fashion, directly influencing not only the duration and intensity of the signaling output, but also its correct location. One process, which requires the precise resolution of spatial information, is actin-based cell motility. This is achieved by coordinating membrane traffic, cell substrate adhesion, and actin remodeling in order to generate propulsive forces responsible for the formation of a diverse set of polarized migratory protrusions, the first steps of cell locomotion. Here, we will discuss how prototypical endocytic molecules control actin dynamics, frequently by linking the core machinery of actin polymerization to the plasma membrane. We will further discuss how endocytosis and recycling ensure spatial restriction of signaling to actin dynamics, thus enabling cells to migrate in response to different extracellular stimuli and in diverse microenvironments adopting diverse motile strategies, which have important implications in relevant physiological and pathological processes, first and foremost cancer cell invasion and dissemination.
UR - http://www.scopus.com/inward/record.url?scp=84919630396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919630396&partnerID=8YFLogxK
U2 - 10.1007/978-90-481-9301-1_3
DO - 10.1007/978-90-481-9301-1_3
M3 - Chapter
AN - SCOPUS:84919630396
SN - 9789048193011
SN - 9789048193004
SP - 59
EP - 84
BT - Actin-based Motility: Cellular, Molecular and Physical Aspects
PB - Springer Netherlands
ER -