Endocytosis and cancer

Research output: Contribution to journalArticle

Abstract

Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.

Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume16
Issue number2
DOIs
Publication statusPublished - Apr 2004

Fingerprint

Endocytosis
Neoplasms
Cell Surface Receptors
Eukaryotic Cells
Homeostasis
Cell Membrane
Ligands
Viruses

Keywords

  • EGFR
  • epithelial growth factor receptor
  • N
  • Notch extracellular domain
  • receptor tyrosine kinase
  • RTK
  • sensory organ precursor
  • SOP

ASJC Scopus subject areas

  • Cell Biology

Cite this

Endocytosis and cancer. / Polo, Simona; Pece, Salvatore; Di Fiore, Pier Paolo.

In: Current Opinion in Cell Biology, Vol. 16, No. 2, 04.2004, p. 156-161.

Research output: Contribution to journalArticle

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