Endocytosis, signaling, and beyond

Pier Paolo Di Fiore, Mark von Zastrow

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The endocytic network comprises a vast and intricate system of membrane-delimited cell entry and cargo sorting routes running between biochemically and functionally distinct intracellular compartments. The endocytic network caters to the organization and redistribution of diverse subcellular components, and mediates appropriate shuttling and processing of materials acquired from neighboring cells or the extracellular milieu. Such trafficking logistics, despite their importance, represent only one facet of endocytic function. The endocytic network also plays a key role in organizing, mediating, and regulating cellular signal transduction events. Conversely, cellular signaling processes tightly control the endocytic pathway at different steps. The present article provides a perspective on the intimate relationships that exist between particular endocytic and cellular signaling processes in mammalian cells, within the context of understanding the impact of this nexus on integrated physiology.

Original languageEnglish
Article numbera016865
JournalCold Spring Harbor perspectives in biology
Volume6
Issue number8
DOIs
Publication statusPublished - 2014

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Cell signaling
Endocytosis
Signal transduction
Physiology
Cell membranes
Sorting
Process control
Logistics
Signal Transduction
Cells
Cell Membrane
Processing
Nexus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Endocytosis, signaling, and beyond. / Di Fiore, Pier Paolo; von Zastrow, Mark.

In: Cold Spring Harbor perspectives in biology, Vol. 6, No. 8, a016865, 2014.

Research output: Contribution to journalArticle

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