Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Valeria Di Giorgi-Gerevini, D. Melchiorri, G. Battaglia, L. Ricci-Vitiani, C. Ciceroni, C. L. Busceti, F. Biagioni, L. Iacovelli, A. M. Canudas, E. Parati, R. De Maria, F. Nicoletti

Research output: Contribution to journalArticle

Abstract

The use of neural progenitor cells (NPCs) is limited by the incomplete knowledge of the extracellular signals regulating their proliferation and survival. We report that cultured mouse NPCs express functional mGlu3 and mGlu5 metabotropic glutamate receptors. Pharmacological blockade of both receptors reduced NPC proliferation and survival, whereas activation of mGlu5 receptors substantially enhanced cell proliferation. Adult mice lacking mGlu5 receptors or treated with mGlu5 or mGlu3 receptor antagonists showed a dramatic reduction in the number of dividing neuroprogenitors present in the subventricular zone and in the dentate gyrus of the hippocampus. These data disclose a novel function of mGlu receptors and offer new potential strategies for the optimization of cell replacement therapy in neurodegenerative disorders.

Original languageEnglish
Pages (from-to)1124-1133
Number of pages10
JournalCell Death and Differentiation
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Cell proliferation
  • Metabotropic glutamate receptors
  • mGlu5 knockout mice
  • Neural progenitor cells
  • Subventricular zone

ASJC Scopus subject areas

  • Cell Biology

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