Abstract
Albumin electrical charge, conformation and hydrophobicity taken as indexes of renal selectivity were evaluated in 8 children affected by steroid-unresponsive nephrotic syndrome associated with glomerulosclerosis or mesangial hypercellularity. These characteristics related to urinary albumin have already been reported to vary markedly in steroid-responsive nephrotic syndrome of minimal-change nephropathy giving rise to new pathogenetic possibilities in this disease. In the steroid-unresponsive nephrotic children albumin was found to be more microheterogenous and cationic in urine than in serum and at the same time it was conformationally altered. Regarding these characteristics, the selectivity properties of the renal filter are similar in steroid-unresponsive nephrotic syndrome, suggesting a pathogenetic connection between these two renal disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 133-138 |
| Number of pages | 6 |
| Journal | Nephron |
| Volume | 52 |
| Issue number | 2 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Nephrology
Cite this
Endogenous albumin as a marker of renal selectivity in steroid-unresponsive nephrotic syndrome. / Ginevri, F.; Ghiggeri, G. M.; Candiano, G.; Oleggini, R.; Bertelli, R.; Perfumo, F.; Queirolo, C.; Gusmano, R.
In: Nephron, Vol. 52, No. 2, 1989, p. 133-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous albumin as a marker of renal selectivity in steroid-unresponsive nephrotic syndrome
AU - Ginevri, F.
AU - Ghiggeri, G. M.
AU - Candiano, G.
AU - Oleggini, R.
AU - Bertelli, R.
AU - Perfumo, F.
AU - Queirolo, C.
AU - Gusmano, R.
PY - 1989
Y1 - 1989
N2 - Albumin electrical charge, conformation and hydrophobicity taken as indexes of renal selectivity were evaluated in 8 children affected by steroid-unresponsive nephrotic syndrome associated with glomerulosclerosis or mesangial hypercellularity. These characteristics related to urinary albumin have already been reported to vary markedly in steroid-responsive nephrotic syndrome of minimal-change nephropathy giving rise to new pathogenetic possibilities in this disease. In the steroid-unresponsive nephrotic children albumin was found to be more microheterogenous and cationic in urine than in serum and at the same time it was conformationally altered. Regarding these characteristics, the selectivity properties of the renal filter are similar in steroid-unresponsive nephrotic syndrome, suggesting a pathogenetic connection between these two renal disorders.
AB - Albumin electrical charge, conformation and hydrophobicity taken as indexes of renal selectivity were evaluated in 8 children affected by steroid-unresponsive nephrotic syndrome associated with glomerulosclerosis or mesangial hypercellularity. These characteristics related to urinary albumin have already been reported to vary markedly in steroid-responsive nephrotic syndrome of minimal-change nephropathy giving rise to new pathogenetic possibilities in this disease. In the steroid-unresponsive nephrotic children albumin was found to be more microheterogenous and cationic in urine than in serum and at the same time it was conformationally altered. Regarding these characteristics, the selectivity properties of the renal filter are similar in steroid-unresponsive nephrotic syndrome, suggesting a pathogenetic connection between these two renal disorders.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024347468&partnerID=8YFLogxK
M3 - Article
C2 - 2739847
AN - SCOPUS:0024347468
VL - 52
SP - 133
EP - 138
JO - Experimental Nephrology
JF - Experimental Nephrology
SN - 0028-2766
IS - 2
ER -