Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor

J. D. Rothstein, A. Guidotti, P. Tinuper, P. Cortelli, P. Avoni, G. Plazzi, E. Lugaresi, P. Montagna, P. Schoch

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

"Endozepines" are endogenous ligands for the benzodiazepine recognition sites on gamma-aminobutyric acid A receptors in the nervous system. Idiopathic recurring stupor (IRS) is a syndrome of spontaneous stupor or coma that is not associated with known metabolic, toxic, or structural abnormalities but can be reversed by flumazenil, a pure benzodiazepine antagonist. We measured endozepine-2 and endozepine-4 by high-performance liquid chromatography and radioreceptor assay in serum and cerebrospinal fluid from three patients with IRS. During episodes of stupor there was a large (up to 300-fold compared with control patients) increase of endozepine-4 content in cerebrospinal fluid and serum, but a return to normal concentrations between attacks. Endozepine-4 may contribute to, or be the cause of, IRS. The reasons for abnormal concentrations of endozepine in blood and brain are unknown.

Original languageEnglish
Pages (from-to)1002-1004
Number of pages3
JournalLancet
Volume340
Issue number8826
DOIs
Publication statusPublished - Oct 24 1992

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Diazepam Binding Inhibitor
Stupor
GABA-A Receptors
Ligands
Benzodiazepines
Cerebrospinal Fluid
Flumazenil
Radioligand Assay
GABA Receptors
Poisons
Coma
Serum
Nervous System
High Pressure Liquid Chromatography
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor. / Rothstein, J. D.; Guidotti, A.; Tinuper, P.; Cortelli, P.; Avoni, P.; Plazzi, G.; Lugaresi, E.; Montagna, P.; Schoch, P.

In: Lancet, Vol. 340, No. 8826, 24.10.1992, p. 1002-1004.

Research output: Contribution to journalArticle

Rothstein, J. D. ; Guidotti, A. ; Tinuper, P. ; Cortelli, P. ; Avoni, P. ; Plazzi, G. ; Lugaresi, E. ; Montagna, P. ; Schoch, P. / Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor. In: Lancet. 1992 ; Vol. 340, No. 8826. pp. 1002-1004.
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AU - Plazzi, G.

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