Endogenous inhibitors of angiogenesis. A historical review

Domenico Ribatti

Research output: Contribution to journalArticlepeer-review


Under physiological conditions, angiogenesis is regulated by the local balance between endogenous stimulators and inhibitors of this process. In pathological states such as chronic inflammation and tumor growth, there is an imbalance between endogenous stimulator and inhibitor levels, leading to an "angiogenic switch". Various inhibitors of angiogenesis, including angiostatin, endostatin and thrombospondins, are found in the body. It is uncertain why the body possesses so many inhibitors, and also how these inhibitors interact to overcome the effects of angiogenesis stimulators. This review summarizes the present knowledge about endogenous inhibitors of angiogenesis.

Original languageEnglish
Pages (from-to)638-644
Number of pages7
JournalLeukemia Research
Issue number5
Publication statusPublished - May 2009


  • Angiogenesis
  • Antiangiogenesis
  • Endogenous inhibitors
  • Tumor growth

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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