Endogenous nitric oxide in patients with chronic heart failure (CHF): Relation to functional impairment and nitrate-containing therapies

Enrico Clini, Maurizio Volterrani, Marco Pagani, Luca Bianchi, Roberto Porta, Lucia Sonia Gile', Amerigo Giordano, Nicolino Ambrosino

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the levels of exhaled nitric oxide (eNO) in patients with chronic heart failure (CHF) according to the functional impairment and the use of nitrate-containing agents. Forty patients (age 55±9 years) were classified according to the NYHA classes I-II (n=18, group 1) and classes III-IV (n=22, group 2), and to the use of nitrate-containing drugs (Nitrate+, Nitrate-). Twenty-two healthy age-related subjects served as controls (group 3). Respiratory function, symptom-limited incremental cycloergometry and resting eNO concentration at peak (FENOp) or plateau (FENOpl) of the single-breath exhalation curve were assessed in all subjects. FENOpl was significantly lower in patients than in controls (7.8±2.7 and 10.6±2.8 ppb, respectively, P2, Watts and FENOpl (r=0.42, P

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalInternational Journal of Cardiology
Volume73
Issue number2
DOIs
Publication statusPublished - Apr 28 2000

Keywords

  • Chronic heart failure
  • Nitric oxide
  • NO donors
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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