TY - JOUR
T1 - Endogenous nitric oxide in patients with chronic heart failure (CHF)
T2 - Relation to functional impairment and nitrate-containing therapies
AU - Clini, Enrico
AU - Volterrani, Maurizio
AU - Pagani, Marco
AU - Bianchi, Luca
AU - Porta, Roberto
AU - Gile', Lucia Sonia
AU - Giordano, Amerigo
AU - Ambrosino, Nicolino
PY - 2000/4/28
Y1 - 2000/4/28
N2 - We assessed the levels of exhaled nitric oxide (eNO) in patients with chronic heart failure (CHF) according to the functional impairment and the use of nitrate-containing agents. Forty patients (age 55±9 years) were classified according to the NYHA classes I-II (n=18, group 1) and classes III-IV (n=22, group 2), and to the use of nitrate-containing drugs (Nitrate+, Nitrate-). Twenty-two healthy age-related subjects served as controls (group 3). Respiratory function, symptom-limited incremental cycloergometry and resting eNO concentration at peak (FENOp) or plateau (FENOpl) of the single-breath exhalation curve were assessed in all subjects. FENOpl was significantly lower in patients than in controls (7.8±2.7 and 10.6±2.8 ppb, respectively, P2, Watts and FENOpl (r=0.42, P
AB - We assessed the levels of exhaled nitric oxide (eNO) in patients with chronic heart failure (CHF) according to the functional impairment and the use of nitrate-containing agents. Forty patients (age 55±9 years) were classified according to the NYHA classes I-II (n=18, group 1) and classes III-IV (n=22, group 2), and to the use of nitrate-containing drugs (Nitrate+, Nitrate-). Twenty-two healthy age-related subjects served as controls (group 3). Respiratory function, symptom-limited incremental cycloergometry and resting eNO concentration at peak (FENOp) or plateau (FENOpl) of the single-breath exhalation curve were assessed in all subjects. FENOpl was significantly lower in patients than in controls (7.8±2.7 and 10.6±2.8 ppb, respectively, P2, Watts and FENOpl (r=0.42, P
KW - Chronic heart failure
KW - Nitric oxide
KW - NO donors
KW - Pulmonary hypertension
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U2 - 10.1016/S0167-5273(00)00211-4
DO - 10.1016/S0167-5273(00)00211-4
M3 - Article
C2 - 10817849
AN - SCOPUS:0034724753
VL - 73
SP - 123
EP - 130
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -