Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension

Stefano Tentori, Elisabetta Messaggio, Elena Brioni, Nunzia Casamassima, Marco Simonini, Laura Zagato, John M. Hamlyn, Paolo Manunta, Chiara Lanzani

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: In the setting of normal sodium (Na) intake, many patients with hypertension have inappropriately elevated plasma aldosterone (Aldo) levels and may be at increased risk for tissue damage. Moreover, other adrenocortical steroids, including endogenous ouabain can stimulate tissue damage. As endogenous ouabain is often elevated in chronically Na-loaded states, is a vasoconstrictor, raises blood pressure (BP), and also promotes tissue fibrosis, we investigated the extent to which plasma Aldo and endogenous ouabain were coelevated among naïve hypertensive patients (NHP). We also investigated the impact of an acute salt load on these steroids, BP, and renal function. METHODS:: NHP (590) were grouped in tertiles based on their baseline plasma Aldo (mean?±?SEM first 7.59?±?0.18, versus third 24.15?±?0.31?ng/dl). Baseline plasma renin activity (2.4?±?0.1 versus 1.2?±?0.1?ng/ml per h, P?

Original languageEnglish
JournalJournal of Hypertension
DOIs
Publication statusAccepted/In press - Jul 21 2016

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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