Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2074 - 2080 |
| Number of pages | 7 |
| Journal | Journal of Hypertension |
| Volume | 34 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Adrenal
- Hormones
- Kidney
- Pressure- natriuresis
- Steroids
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension. / Tentori, Stefano; Messaggio, Elisabetta; Brioni, Elena; Casamassima, Nunzia; Simonini, Marco; Zagato, Laura; Hamlyn, John M.; Manunta, Paolo; Lanzani, Chiara.
In: Journal of Hypertension, Vol. 34, No. 10, 2016, p. 2074 - 2080.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension
AU - Tentori, Stefano
AU - Messaggio, Elisabetta
AU - Brioni, Elena
AU - Casamassima, Nunzia
AU - Simonini, Marco
AU - Zagato, Laura
AU - Hamlyn, John M.
AU - Manunta, Paolo
AU - Lanzani, Chiara
PY - 2016
Y1 - 2016
N2 - Objective: In the setting of normal sodium (Na) intake, many patients with hypertension have inappropriately elevated plasma aldosterone (Aldo) levels and may be at increased risk for tissue damage. Moreover, other adrenocortical steroids, including endogenous ouabain can stimulate tissue damage. As endogenous ouabain is often elevated in chronically Na-loaded states, is a vasoconstrictor, raises blood pressure (BP), and also promotes tissue fibrosis, we investigated the extent to which plasma Aldo and endogenous ouabain were coelevated among naïve hypertensive patients (NHP). We also investigated the impact of an acute salt load on these steroids, BP, and renal function. Methods: NHP (590) were grouped in tertiles based on their baseline plasma Aldo (mean±SEM first 7.59±0.18, versus third 24.15±0.31 ng/dl). Baseline plasma renin activity (2.4±0.1 versus 1.2±0.1 ng/ml per h, P
AB - Objective: In the setting of normal sodium (Na) intake, many patients with hypertension have inappropriately elevated plasma aldosterone (Aldo) levels and may be at increased risk for tissue damage. Moreover, other adrenocortical steroids, including endogenous ouabain can stimulate tissue damage. As endogenous ouabain is often elevated in chronically Na-loaded states, is a vasoconstrictor, raises blood pressure (BP), and also promotes tissue fibrosis, we investigated the extent to which plasma Aldo and endogenous ouabain were coelevated among naïve hypertensive patients (NHP). We also investigated the impact of an acute salt load on these steroids, BP, and renal function. Methods: NHP (590) were grouped in tertiles based on their baseline plasma Aldo (mean±SEM first 7.59±0.18, versus third 24.15±0.31 ng/dl). Baseline plasma renin activity (2.4±0.1 versus 1.2±0.1 ng/ml per h, P
KW - Adrenal
KW - Hormones
KW - Kidney
KW - Pressure- natriuresis
KW - Steroids
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U2 - 10.1097/HJH.0000000000001042
DO - 10.1097/HJH.0000000000001042
M3 - Article
VL - 34
SP - 2074
EP - 2080
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 10
ER -