Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension

Stefano Tentori, Elisabetta Messaggio, Elena Brioni, Nunzia Casamassima, Marco Simonini, Laura Zagato, John M. Hamlyn, Paolo Manunta, Chiara Lanzani

Research output: Contribution to journalArticle

Abstract

Objective: In the setting of normal sodium (Na) intake, many patients with hypertension have inappropriately elevated plasma aldosterone (Aldo) levels and may be at increased risk for tissue damage. Moreover, other adrenocortical steroids, including endogenous ouabain can stimulate tissue damage. As endogenous ouabain is often elevated in chronically Na-loaded states, is a vasoconstrictor, raises blood pressure (BP), and also promotes tissue fibrosis, we investigated the extent to which plasma Aldo and endogenous ouabain were coelevated among naïve hypertensive patients (NHP). We also investigated the impact of an acute salt load on these steroids, BP, and renal function. Methods: NHP (590) were grouped in tertiles based on their baseline plasma Aldo (mean±SEM first 7.59±0.18, versus third 24.15±0.31 ng/dl). Baseline plasma renin activity (2.4±0.1 versus 1.2±0.1 ng/ml per h, P
Original languageEnglish
Pages (from-to)2074 - 2080
Number of pages7
JournalJournal of Hypertension
Volume34
Issue number10
DOIs
Publication statusPublished - 2016

Fingerprint

Ouabain
Aldosterone
Steroids
Blood Pressure
Vasoconstrictor Agents
Renin
Fibrosis
Salts
Sodium
Hypertension
Kidney
Essential Hypertension

Keywords

  • Adrenal
  • Hormones
  • Kidney
  • Pressure- natriuresis
  • Steroids

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension. / Tentori, Stefano; Messaggio, Elisabetta; Brioni, Elena; Casamassima, Nunzia; Simonini, Marco; Zagato, Laura; Hamlyn, John M.; Manunta, Paolo; Lanzani, Chiara.

In: Journal of Hypertension, Vol. 34, No. 10, 2016, p. 2074 - 2080.

Research output: Contribution to journalArticle

Tentori, Stefano ; Messaggio, Elisabetta ; Brioni, Elena ; Casamassima, Nunzia ; Simonini, Marco ; Zagato, Laura ; Hamlyn, John M. ; Manunta, Paolo ; Lanzani, Chiara. / Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension. In: Journal of Hypertension. 2016 ; Vol. 34, No. 10. pp. 2074 - 2080.
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AU - Tentori, Stefano

AU - Messaggio, Elisabetta

AU - Brioni, Elena

AU - Casamassima, Nunzia

AU - Simonini, Marco

AU - Zagato, Laura

AU - Hamlyn, John M.

AU - Manunta, Paolo

AU - Lanzani, Chiara

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AB - Objective: In the setting of normal sodium (Na) intake, many patients with hypertension have inappropriately elevated plasma aldosterone (Aldo) levels and may be at increased risk for tissue damage. Moreover, other adrenocortical steroids, including endogenous ouabain can stimulate tissue damage. As endogenous ouabain is often elevated in chronically Na-loaded states, is a vasoconstrictor, raises blood pressure (BP), and also promotes tissue fibrosis, we investigated the extent to which plasma Aldo and endogenous ouabain were coelevated among naïve hypertensive patients (NHP). We also investigated the impact of an acute salt load on these steroids, BP, and renal function. Methods: NHP (590) were grouped in tertiles based on their baseline plasma Aldo (mean±SEM first 7.59±0.18, versus third 24.15±0.31 ng/dl). Baseline plasma renin activity (2.4±0.1 versus 1.2±0.1 ng/ml per h, P

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