Endogenous ouabain in cardiovascular function and disease

Paolo Manunta, Mara Ferrandi, Giuseppe Bianchi, John M. Hamlyn

Research output: Contribution to journalArticlepeer-review

Abstract

An endogenous ouabain has been isolated and conclusively identified from several mammalian tissues, including human plasma, by a number of independent laboratories. Substantial evidence from independent laboratories in several continents is consistent with an adrenal source for most if not all of the circulating endogenous ouabain. Accumulating evidence suggests that circulating levels of endogenous ouabain in humans are modulated by dietary salt and chronic volume status. Endogenous ouabain is linked significantly with vascular function in hypertension and likely impacts the pathogenesis of heart and renal failure. Moreover, the molecular mechanism of endogenous ouabain-linked hypertension involves the sodium pump/sodium-calcium exchange duet. The outstanding analytical issues include the elucidation of distal events in the biosynthetic pathway for endogenous ouabain and identification of molecular mechanisms that regulate its secretion and clearance.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalJournal of Hypertension
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Digitalis-like factor
  • Hypertension
  • Na pump inhibitor
  • Natriuresis
  • Renal
  • Sodium

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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