Endogenous ouabain in ménière's disease

Roberto Teggi, Laura Zagato, Simona Delli Carpini, Elisabetta Messaggio, Nunzia Casamassima, Chiara Lanzani, Paolo Manunta, Mario Bussi

Research output: Contribution to journalArticle

Abstract

Objective: Endogenous Ouabain (EO) has been demonstrated to modulate the activity of Na+, K+-ATPase. Our purpose was to measure plasma levels of EO in Ménière's Disease (MD) subjects as a possible predisposing factor to developing and maintaining hydrops. Study Design: Case-control study. Settings: University hospital. Patients: Thirty-nine MD subjects and 29 controls with a lifetime negative history for vertigo and dizziness. Main Outcome Measures: Plasma levels of EO. Results: Plasma EO in MD subjects was in the range between 33 and 504 pmol/L (median, 135.5 pmol/L), whereas in the control group, plasma EO varied between 70 and 724 pmol/L (median, 205 pmol/L). The Mann-Whitney U test detected a statistically significant difference (p = 0.0001). Conclusion:: Low plasma levels of EO have been proposed to augment Na-K pump activity, whereas high EO levels show an inhibitory effect on the pump activity. A proper pump activity may be necessary to keep the right ionic amount and osmolarity in endolymph. Although other possibilities may be considered, we suggest that altered control mechanisms of pump activity may be related to the pathogenesis and maintenance of MD.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalOtology and Neurotology
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Ouabain
Endolymph
Vertigo
Dizziness
Nonparametric Statistics
Causality
Osmolar Concentration
Case-Control Studies
Edema
History
Maintenance
Outcome Assessment (Health Care)
Control Groups

Keywords

  • Inner ear hydrops
  • K ATPase
  • Ménière's disease
  • Na
  • Ouabain
  • Recurrent vertigo

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology
  • Sensory Systems
  • Medicine(all)

Cite this

Endogenous ouabain in ménière's disease. / Teggi, Roberto; Zagato, Laura; Delli Carpini, Simona; Messaggio, Elisabetta; Casamassima, Nunzia; Lanzani, Chiara; Manunta, Paolo; Bussi, Mario.

In: Otology and Neurotology, Vol. 31, No. 1, 01.2010, p. 153-156.

Research output: Contribution to journalArticle

Teggi, Roberto ; Zagato, Laura ; Delli Carpini, Simona ; Messaggio, Elisabetta ; Casamassima, Nunzia ; Lanzani, Chiara ; Manunta, Paolo ; Bussi, Mario. / Endogenous ouabain in ménière's disease. In: Otology and Neurotology. 2010 ; Vol. 31, No. 1. pp. 153-156.
@article{225c3a2277f440a9a0174c69672698ce,
title = "Endogenous ouabain in m{\'e}ni{\`e}re's disease",
abstract = "Objective: Endogenous Ouabain (EO) has been demonstrated to modulate the activity of Na+, K+-ATPase. Our purpose was to measure plasma levels of EO in M{\'e}ni{\`e}re's Disease (MD) subjects as a possible predisposing factor to developing and maintaining hydrops. Study Design: Case-control study. Settings: University hospital. Patients: Thirty-nine MD subjects and 29 controls with a lifetime negative history for vertigo and dizziness. Main Outcome Measures: Plasma levels of EO. Results: Plasma EO in MD subjects was in the range between 33 and 504 pmol/L (median, 135.5 pmol/L), whereas in the control group, plasma EO varied between 70 and 724 pmol/L (median, 205 pmol/L). The Mann-Whitney U test detected a statistically significant difference (p = 0.0001). Conclusion:: Low plasma levels of EO have been proposed to augment Na-K pump activity, whereas high EO levels show an inhibitory effect on the pump activity. A proper pump activity may be necessary to keep the right ionic amount and osmolarity in endolymph. Although other possibilities may be considered, we suggest that altered control mechanisms of pump activity may be related to the pathogenesis and maintenance of MD.",
keywords = "Inner ear hydrops, K ATPase, M{\'e}ni{\`e}re's disease, Na, Ouabain, Recurrent vertigo",
author = "Roberto Teggi and Laura Zagato and {Delli Carpini}, Simona and Elisabetta Messaggio and Nunzia Casamassima and Chiara Lanzani and Paolo Manunta and Mario Bussi",
year = "2010",
month = "1",
doi = "10.1097/MAO.0b013e3181c0eaba",
language = "English",
volume = "31",
pages = "153--156",
journal = "Otology and Neurotology",
issn = "1531-7129",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Endogenous ouabain in ménière's disease

AU - Teggi, Roberto

AU - Zagato, Laura

AU - Delli Carpini, Simona

AU - Messaggio, Elisabetta

AU - Casamassima, Nunzia

AU - Lanzani, Chiara

AU - Manunta, Paolo

AU - Bussi, Mario

PY - 2010/1

Y1 - 2010/1

N2 - Objective: Endogenous Ouabain (EO) has been demonstrated to modulate the activity of Na+, K+-ATPase. Our purpose was to measure plasma levels of EO in Ménière's Disease (MD) subjects as a possible predisposing factor to developing and maintaining hydrops. Study Design: Case-control study. Settings: University hospital. Patients: Thirty-nine MD subjects and 29 controls with a lifetime negative history for vertigo and dizziness. Main Outcome Measures: Plasma levels of EO. Results: Plasma EO in MD subjects was in the range between 33 and 504 pmol/L (median, 135.5 pmol/L), whereas in the control group, plasma EO varied between 70 and 724 pmol/L (median, 205 pmol/L). The Mann-Whitney U test detected a statistically significant difference (p = 0.0001). Conclusion:: Low plasma levels of EO have been proposed to augment Na-K pump activity, whereas high EO levels show an inhibitory effect on the pump activity. A proper pump activity may be necessary to keep the right ionic amount and osmolarity in endolymph. Although other possibilities may be considered, we suggest that altered control mechanisms of pump activity may be related to the pathogenesis and maintenance of MD.

AB - Objective: Endogenous Ouabain (EO) has been demonstrated to modulate the activity of Na+, K+-ATPase. Our purpose was to measure plasma levels of EO in Ménière's Disease (MD) subjects as a possible predisposing factor to developing and maintaining hydrops. Study Design: Case-control study. Settings: University hospital. Patients: Thirty-nine MD subjects and 29 controls with a lifetime negative history for vertigo and dizziness. Main Outcome Measures: Plasma levels of EO. Results: Plasma EO in MD subjects was in the range between 33 and 504 pmol/L (median, 135.5 pmol/L), whereas in the control group, plasma EO varied between 70 and 724 pmol/L (median, 205 pmol/L). The Mann-Whitney U test detected a statistically significant difference (p = 0.0001). Conclusion:: Low plasma levels of EO have been proposed to augment Na-K pump activity, whereas high EO levels show an inhibitory effect on the pump activity. A proper pump activity may be necessary to keep the right ionic amount and osmolarity in endolymph. Although other possibilities may be considered, we suggest that altered control mechanisms of pump activity may be related to the pathogenesis and maintenance of MD.

KW - Inner ear hydrops

KW - K ATPase

KW - Ménière's disease

KW - Na

KW - Ouabain

KW - Recurrent vertigo

UR - http://www.scopus.com/inward/record.url?scp=74349107204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74349107204&partnerID=8YFLogxK

U2 - 10.1097/MAO.0b013e3181c0eaba

DO - 10.1097/MAO.0b013e3181c0eaba

M3 - Article

C2 - 19887986

AN - SCOPUS:74349107204

VL - 31

SP - 153

EP - 156

JO - Otology and Neurotology

JF - Otology and Neurotology

SN - 1531-7129

IS - 1

ER -