Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Paula Jakszyn, Sheila Bingham, Guillem Pera, Antonio Agudo, Robert Luben, Ailsa Welch, Heiner Boeing, Giuseppe del Giudice, Domenico Palli, Calogero Saieva, Vittorio Krogh, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Göran Hallmans, María José Sanchez, Nerea Larrañaga, Aurelio Barricarte & 24 others María Dolores Chirlaque, José R. Quirós, Timothy J. Key, Naomi Allen, Eiliv Lund, Fátima Carneiro, Jakob Linseisen, Gabriele Nagel, Kim Overvad, Anne Tjonneland, Anja Olsen, H. Bas Bueno-de-Mesquita, Marga O. Ocké, Petra H M Peeters, Mattijs E. Numans, Françoise Clavel-Chapelon, Antonia Trichopoulou, Claus Fenger, Roger Stenling, Pietro Ferrari, Mazda Jenab, Teresa Norat, Elio Riboli, Carlos A. Gonzalez

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Abstract

The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was

Original languageEnglish
Pages (from-to)1497-1501
Number of pages5
JournalCarcinogenesis
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2006

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Nitroso Compounds
Stomach Neoplasms
Dimethylnitrosamine
Neoplasms
Helicobacter pylori
Meat
Ascorbic Acid
Iron
Antibodies

ASJC Scopus subject areas

  • Cancer Research

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Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. / Jakszyn, Paula; Bingham, Sheila; Pera, Guillem; Agudo, Antonio; Luben, Robert; Welch, Ailsa; Boeing, Heiner; del Giudice, Giuseppe; Palli, Domenico; Saieva, Calogero; Krogh, Vittorio; Sacerdote, Carlotta; Tumino, Rosario; Panico, Salvatore; Berglund, Göran; Simán, Henrik; Hallmans, Göran; Sanchez, María José; Larrañaga, Nerea; Barricarte, Aurelio; Chirlaque, María Dolores; Quirós, José R.; Key, Timothy J.; Allen, Naomi; Lund, Eiliv; Carneiro, Fátima; Linseisen, Jakob; Nagel, Gabriele; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Bueno-de-Mesquita, H. Bas; Ocké, Marga O.; Peeters, Petra H M; Numans, Mattijs E.; Clavel-Chapelon, Françoise; Trichopoulou, Antonia; Fenger, Claus; Stenling, Roger; Ferrari, Pietro; Jenab, Mazda; Norat, Teresa; Riboli, Elio; Gonzalez, Carlos A.

In: Carcinogenesis, Vol. 27, No. 7, 07.2006, p. 1497-1501.

Research output: Contribution to journalArticle

Jakszyn, P, Bingham, S, Pera, G, Agudo, A, Luben, R, Welch, A, Boeing, H, del Giudice, G, Palli, D, Saieva, C, Krogh, V, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Simán, H, Hallmans, G, Sanchez, MJ, Larrañaga, N, Barricarte, A, Chirlaque, MD, Quirós, JR, Key, TJ, Allen, N, Lund, E, Carneiro, F, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Olsen, A, Bueno-de-Mesquita, HB, Ocké, MO, Peeters, PHM, Numans, ME, Clavel-Chapelon, F, Trichopoulou, A, Fenger, C, Stenling, R, Ferrari, P, Jenab, M, Norat, T, Riboli, E & Gonzalez, CA 2006, 'Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study', Carcinogenesis, vol. 27, no. 7, pp. 1497-1501. https://doi.org/10.1093/carcin/bgl019
Jakszyn, Paula ; Bingham, Sheila ; Pera, Guillem ; Agudo, Antonio ; Luben, Robert ; Welch, Ailsa ; Boeing, Heiner ; del Giudice, Giuseppe ; Palli, Domenico ; Saieva, Calogero ; Krogh, Vittorio ; Sacerdote, Carlotta ; Tumino, Rosario ; Panico, Salvatore ; Berglund, Göran ; Simán, Henrik ; Hallmans, Göran ; Sanchez, María José ; Larrañaga, Nerea ; Barricarte, Aurelio ; Chirlaque, María Dolores ; Quirós, José R. ; Key, Timothy J. ; Allen, Naomi ; Lund, Eiliv ; Carneiro, Fátima ; Linseisen, Jakob ; Nagel, Gabriele ; Overvad, Kim ; Tjonneland, Anne ; Olsen, Anja ; Bueno-de-Mesquita, H. Bas ; Ocké, Marga O. ; Peeters, Petra H M ; Numans, Mattijs E. ; Clavel-Chapelon, Françoise ; Trichopoulou, Antonia ; Fenger, Claus ; Stenling, Roger ; Ferrari, Pietro ; Jenab, Mazda ; Norat, Teresa ; Riboli, Elio ; Gonzalez, Carlos A. / Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. In: Carcinogenesis. 2006 ; Vol. 27, No. 7. pp. 1497-1501.
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AU - Bingham, Sheila

AU - Pera, Guillem

AU - Agudo, Antonio

AU - Luben, Robert

AU - Welch, Ailsa

AU - Boeing, Heiner

AU - del Giudice, Giuseppe

AU - Palli, Domenico

AU - Saieva, Calogero

AU - Krogh, Vittorio

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Berglund, Göran

AU - Simán, Henrik

AU - Hallmans, Göran

AU - Sanchez, María José

AU - Larrañaga, Nerea

AU - Barricarte, Aurelio

AU - Chirlaque, María Dolores

AU - Quirós, José R.

AU - Key, Timothy J.

AU - Allen, Naomi

AU - Lund, Eiliv

AU - Carneiro, Fátima

AU - Linseisen, Jakob

AU - Nagel, Gabriele

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Bueno-de-Mesquita, H. Bas

AU - Ocké, Marga O.

AU - Peeters, Petra H M

AU - Numans, Mattijs E.

AU - Clavel-Chapelon, Françoise

AU - Trichopoulou, Antonia

AU - Fenger, Claus

AU - Stenling, Roger

AU - Ferrari, Pietro

AU - Jenab, Mazda

AU - Norat, Teresa

AU - Riboli, Elio

AU - Gonzalez, Carlos A.

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