TY - JOUR
T1 - Endoglin
T2 - An accessory component of the TGF-β-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies
AU - Fonsatti, Ester
AU - Del Vecchio, Luigi
AU - Altomonte, Maresa
AU - Sigalotti, Luca
AU - Nicotra, Maria Rita
AU - Coral, Sandra
AU - Natali, Pier Giorgio
AU - Maio, Michele
PY - 2001
Y1 - 2001
N2 - Endoglin (CD105) is a cell membrane glycoprotein over-expressed on highly proliferating endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within benign and malignant tissues. CD105 binds several factors of the Transforming Growth Factor (TGF)-β superfamily, and its over-expression modulates cellular responses to TGF-β1. The complex of experimental findings accumulated in the last few years strongly indicate that CD105 is a powerful marker of angiogenesis, and that it might play a critical role in the pathogenesis of vascular diseases and in tumor progression. In this paper, we will review the structural, biological and functional features of CD105, as well as its distribution within normal and neoplastic tissues, emphasizing its foreseeable role as a molecular target for new diagnostic and bioimmunotherapeutic approaches in human malignancies.
AB - Endoglin (CD105) is a cell membrane glycoprotein over-expressed on highly proliferating endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within benign and malignant tissues. CD105 binds several factors of the Transforming Growth Factor (TGF)-β superfamily, and its over-expression modulates cellular responses to TGF-β1. The complex of experimental findings accumulated in the last few years strongly indicate that CD105 is a powerful marker of angiogenesis, and that it might play a critical role in the pathogenesis of vascular diseases and in tumor progression. In this paper, we will review the structural, biological and functional features of CD105, as well as its distribution within normal and neoplastic tissues, emphasizing its foreseeable role as a molecular target for new diagnostic and bioimmunotherapeutic approaches in human malignancies.
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U2 - 10.1002/jcp.1095
DO - 10.1002/jcp.1095
M3 - Article
C2 - 11382917
AN - SCOPUS:0035017536
VL - 188
SP - 1
EP - 7
JO - Journal of cellular and comparative physiology
JF - Journal of cellular and comparative physiology
SN - 0021-9541
IS - 1
ER -