Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry

S. Saponaro; B. Farina; Lars H. Murrer; Emanuele Pignoli; Raffaella Rizzo; Willem M. Star; Stefano Tomatis; Renato Marchesini

Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry

S. Saponaro, B. Farina, Lars H. Murrer, Emanuele Pignoli, Raffaella Rizzo, Willem M. Star, Stefano Tomatis, Renato Marchesini

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A Monte Carlo model has been developed to simulate the fluence distribution in a fully cylindrical geometry, when a finite linear light source is placed on the axis of a hollow organ during PDT treatment. Height and radius of the cavity, scattering and absorption coefficients, anisotropy factor (g), refractive index of medium and cavity are required as input by the MC code. Data obtained from this model were subsequently compared with experimental results using a tissue simulating phantom. An aqueous solution of Intralipid-10 percent and black ink were used to simulate optical properties. A helium-neon laser, coupled to a cylindrical diffuser was employed as light source. A good agreement between the MC simulations and experimental measurements was found.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	Hans J. Albrecht, Guy P. Delacretaz, Thomas H. Meier, Rudolf W. Steiner, Lars O. Svaasand
Pages	86-95
Number of pages	10
Volume	2923
Publication status	Published - 1996
Event	Laser-Tissue Interaction and Tissue Optics II - Vienna, Austria Duration: Sep 7 1996 → Sep 10 1996

Other

Other	Laser-Tissue Interaction and Tissue Optics II
City	Vienna, Austria
Period	9/7/96 → 9/10/96

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

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Saponaro, S., Farina, B., Murrer, L. H., Pignoli, E., Rizzo, R., Star, W. M., Tomatis, S., & Marchesini, R. (1996). Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry. In H. J. Albrecht, G. P. Delacretaz, T. H. Meier, R. W. Steiner, & L. O. Svaasand (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2923, pp. 86-95)

Endoluminal photodynamic therapy : influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry. / Saponaro, S.; Farina, B.; Murrer, Lars H.; Pignoli, Emanuele; Rizzo, Raffaella; Star, Willem M.; Tomatis, Stefano; Marchesini, Renato.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Hans J. Albrecht; Guy P. Delacretaz; Thomas H. Meier; Rudolf W. Steiner; Lars O. Svaasand. Vol. 2923 1996. p. 86-95.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Saponaro, S, Farina, B, Murrer, LH, Pignoli, E, Rizzo, R, Star, WM, Tomatis, S & Marchesini, R 1996, Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry. in HJ Albrecht, GP Delacretaz, TH Meier, RW Steiner & LO Svaasand (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2923, pp. 86-95, Laser-Tissue Interaction and Tissue Optics II, Vienna, Austria, 9/7/96.

Saponaro S, Farina B, Murrer LH, Pignoli E, Rizzo R, Star WM et al. Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry. In Albrecht HJ, Delacretaz GP, Meier TH, Steiner RW, Svaasand LO, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2923. 1996. p. 86-95

Saponaro, S. ; Farina, B. ; Murrer, Lars H. ; Pignoli, Emanuele ; Rizzo, Raffaella ; Star, Willem M. ; Tomatis, Stefano ; Marchesini, Renato. / Endoluminal photodynamic therapy : influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry. Proceedings of SPIE - The International Society for Optical Engineering. editor / Hans J. Albrecht ; Guy P. Delacretaz ; Thomas H. Meier ; Rudolf W. Steiner ; Lars O. Svaasand. Vol. 2923 1996. pp. 86-95

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AU - Pignoli, Emanuele

AU - Rizzo, Raffaella

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AB - A Monte Carlo model has been developed to simulate the fluence distribution in a fully cylindrical geometry, when a finite linear light source is placed on the axis of a hollow organ during PDT treatment. Height and radius of the cavity, scattering and absorption coefficients, anisotropy factor (g), refractive index of medium and cavity are required as input by the MC code. Data obtained from this model were subsequently compared with experimental results using a tissue simulating phantom. An aqueous solution of Intralipid-10 percent and black ink were used to simulate optical properties. A helium-neon laser, coupled to a cylindrical diffuser was employed as light source. A good agreement between the MC simulations and experimental measurements was found.

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