Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry

S. Saponaro, B. Farina, Lars H. Murrer, Emanuele Pignoli, Raffaella Rizzo, Willem M. Star, Stefano Tomatis, Renato Marchesini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A Monte Carlo model has been developed to simulate the fluence distribution in a fully cylindrical geometry, when a finite linear light source is placed on the axis of a hollow organ during PDT treatment. Height and radius of the cavity, scattering and absorption coefficients, anisotropy factor (g), refractive index of medium and cavity are required as input by the MC code. Data obtained from this model were subsequently compared with experimental results using a tissue simulating phantom. An aqueous solution of Intralipid-10 percent and black ink were used to simulate optical properties. A helium-neon laser, coupled to a cylindrical diffuser was employed as light source. A good agreement between the MC simulations and experimental measurements was found.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsHans J. Albrecht, Guy P. Delacretaz, Thomas H. Meier, Rudolf W. Steiner, Lars O. Svaasand
Pages86-95
Number of pages10
Volume2923
Publication statusPublished - 1996
EventLaser-Tissue Interaction and Tissue Optics II - Vienna, Austria
Duration: Sep 7 1996Sep 10 1996

Other

OtherLaser-Tissue Interaction and Tissue Optics II
CityVienna, Austria
Period9/7/969/10/96

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry'. Together they form a unique fingerprint.

  • Cite this

    Saponaro, S., Farina, B., Murrer, L. H., Pignoli, E., Rizzo, R., Star, W. M., Tomatis, S., & Marchesini, R. (1996). Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry. In H. J. Albrecht, G. P. Delacretaz, T. H. Meier, R. W. Steiner, & L. O. Svaasand (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2923, pp. 86-95)