Endometrial cancer: Analysis of treatment modality in Italy

P. Zola, M. G. Bau, A. Gadducci, F. Landoni, T. Maggino, C. Romagnolo, E. Sartori, L. Fuso, E. Jacomuzzi, A. Magistris

Research output: Contribution to journalArticle

Abstract

Objective: Endometrial carcinoma is the most common gynaecologic malignancy; we decided to analyse how this carcinoma is usually treated in Italy in order to define what the most questionable issues are. Methods: We mailed a questionnaire to all the gynaecologic departments of medical schools and 186 general hospitals reported in the mailing list of the Italian Society of Gynaecologic Oncology and we evaluated the answers. Results: We did not find any significant difference between the answers obtained from general hospitals and university centres. The majority of the centres declared not to adopt a different treatment according to menopausal status (76%) and age (83%); lymphadenectomy is performed systematically in 36% of the centres, 4% do not carry it out at all, while the remaining 60% declared that they perform it only in the presence of particular clinico-surgical conditions. More than half of the centres adopted cervico-hysteroscopy as a standard presurgical procedure in staging of endometrial cancer. Simple hysterectomy with bilateral salpingoophorectomy is still considered the treatment of choice in this kind of neoplasia since radical surgery is usually performed in 5.5% of the centres and the remaining 71.4% adopted enlarged hysterectomy when negative prognostic factors are present. Adjuvant treatment in FIGO stage Ic is recommended in 94% of the centres, while there is no agreement about adjuvant treatment in pathological stage I with negative lymph-nodes. Conclusions: Our data confirm the need to design guidelines in the management of endometrial carcinoma in clinical practice, while waiting for results of some ongoing clinical trials devoted to exploring adjuvant therapy in high risk patients.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalItalian Journal of Gynaecology and Obstetrics
Volume11
Issue number1
Publication statusPublished - 1999

Keywords

  • Clinical trials
  • Endometrial cancer
  • Radiotherapy
  • Surgery
  • Treatment

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Zola, P., Bau, M. G., Gadducci, A., Landoni, F., Maggino, T., Romagnolo, C., Sartori, E., Fuso, L., Jacomuzzi, E., & Magistris, A. (1999). Endometrial cancer: Analysis of treatment modality in Italy. Italian Journal of Gynaecology and Obstetrics, 11(1), 1-8.