Endometrial hyperplasia and endometrial carcinoma induce a vasoproliferative response in the chick embryo chorioallantoic membrane

Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Ten specimens of endometrial adenocarcinoma, of endometrial hyperplasia and uterine prolapse (the latter used as controls), respectively, were grafted onto the chick embryo chorioallantoic membrane (CAM) to investigate their angiogenic activity. The vasoproliferative response was assessed four days after grafting on histologic sections by a planimetric point-count method. Microvessel counts in the CAM area under and around the implants were significantly higher in endometrial adenocarcinoma than in endometrial hyperplasia and in the latter over the controls. These findings show that endometrial hyperplasia and endometrial adenocarcinoma are angiogenic. These results confirm previous observation that angiogenic activity is both a marker of the passage between preneoplastic to neoplastic status and an event that influences tumour progression.

Original languageEnglish
Pages (from-to)1149-1153
Number of pages5
JournalInternational Journal of Oncology
Volume8
Issue number6
Publication statusPublished - 1996

Keywords

  • angiogenesis
  • chorioallantoic membrane
  • endometrial adenocarcinoma
  • endometrial hyperplasia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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