Endometrial morphology and ultrasound vascular findings. A randomized trial after intramuscular and vaginal progesterone supplementation in IVF

Guido Ragni, Stefania Piloni, Piero Rossi, Silvestro Carinelli, Luciana De Lauretis, Walter Vegetti, Pier Giorgio Crosignani

Research output: Contribution to journalArticle

Abstract

Luteal-phase supplementation has proved necessary in Gn-RH analog and human gonadotropin-stimulated cycles. We studied the effects of vaginally and intramuscularly delivered progesterone on the endometrium. Thirty patients enrolled in an IVF program without embryo transfer due to absence of fertilization were included in the study. Patients were randomly allocated to two treatment groups. Group A (n = 15) was administered 200 mg progesterone b.i.d. by the vaginal route (Esolut, Angelini) starting on the day of oocyte pick up and group B (n = 15) was given 100 mg intramuscular progesterone once daily (Prontogest, Amsa). Six days after HCG administration, biopsies were obtained for endometrial histological maturation and estrogen (ER) and progesterone (PR) receptor analyses. In addition, ultrasound measurements of endometrial thickness were made and uterine and myometrial artery flow was determined. Serum concentrations of estriol and progesterone were measured on the day of HCG, at oocyte pick up and at endometrial biopsy. The two treatment groups were similar in terms of follicular phase parameters during superovulation with Gn-RH analog and gonadotropin. Histologic, receptor and ultrasonographic analyses showed no significant differences between the two treatment groups. Our results indicate that both intramuscular and vaginal progesterone are equally effective on the endometrium.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume47
Issue number3
Publication statusPublished - 1999

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Keywords

  • Endometrium
  • In vitro fertilization
  • Progesterone
  • Route of supplementation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Ragni, G., Piloni, S., Rossi, P., Carinelli, S., De Lauretis, L., Vegetti, W., & Crosignani, P. G. (1999). Endometrial morphology and ultrasound vascular findings. A randomized trial after intramuscular and vaginal progesterone supplementation in IVF. Gynecologic and Obstetric Investigation, 47(3), 151-156.