TY - JOUR
T1 - Endometrial patterns during danazol and buserelin therapy for endometriosis
T2 - Comparative structural and ultrastructural study
AU - Fedele, L.
AU - Marchini, M.
AU - Bianchi, S.
AU - Baglioni, A.
AU - Bocciolone, L.
AU - Nava, S.
PY - 1990
Y1 - 1990
N2 - We studied endometrial structure and ultrastructure in serial biopsy specimens from patients with endometriosis treated with danazol (N = 19) or intranasal buserelin (N = 13) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The specimens were studied by light, scanning, and transmission electron microscopy. Six morphometric indices were evaluated. Danazol produced a progestational effect on endometrial glands and stroma associated with marked hypotrphy of the mucosa, and buserelin treatment resulted in weakly proliferative or inactive mucosa. Both drugs induced noncyclicity and hypotrophy of endometrium although with different mechanisms of action, and it is suggested that they may have similar effects on ectopic endometrium. Because the atrophic effect of danazol appeared earlier than that of buserelin, the former could be recommended for short-term therapy.
AB - We studied endometrial structure and ultrastructure in serial biopsy specimens from patients with endometriosis treated with danazol (N = 19) or intranasal buserelin (N = 13) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The specimens were studied by light, scanning, and transmission electron microscopy. Six morphometric indices were evaluated. Danazol produced a progestational effect on endometrial glands and stroma associated with marked hypotrphy of the mucosa, and buserelin treatment resulted in weakly proliferative or inactive mucosa. Both drugs induced noncyclicity and hypotrophy of endometrium although with different mechanisms of action, and it is suggested that they may have similar effects on ectopic endometrium. Because the atrophic effect of danazol appeared earlier than that of buserelin, the former could be recommended for short-term therapy.
UR - http://www.scopus.com/inward/record.url?scp=0025338336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025338336&partnerID=8YFLogxK
M3 - Article
C2 - 2113661
AN - SCOPUS:0025338336
VL - 76
SP - 79
EP - 84
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 1
ER -