Abstract
We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.
Original language | English |
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Pages (from-to) | 137-143 |
Number of pages | 7 |
Journal | European Journal of Obstetrics and Gynecology and Reproductive Biology |
Volume | 40 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jul 1 1991 |
Keywords
- Cyproterone acetate
- Danazol
- Endometrium
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine