Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study

Maurizio Marchini; Luigi Fedele; Stefano Bianchi; Luisa Arcaini; Diana Brioschi; Giuliana Di Nola

doi:10.1016/0028-2243(91)90105-T

Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study

Maurizio Marchini, Luigi Fedele, Stefano Bianchi, Luisa Arcaini, Diana Brioschi, Giuliana Di Nola

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.

Original language	English
Pages (from-to)	137-143
Number of pages	7
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/0028-2243(91)90105-T
Publication status	Published - Jul 1 1991

Keywords

Cyproterone acetate
Danazol
Endometrium

ASJC Scopus subject areas

Obstetrics and Gynaecology
Reproductive Medicine

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10.1016/0028-2243(91)90105-T

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Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis : structural and ultrastructural study. / Marchini, Maurizio; Fedele, Luigi; Bianchi, Stefano; Arcaini, Luisa; Brioschi, Diana; Di Nola, Giuliana.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 40, No. 2, 01.07.1991, p. 137-143.

Research output: Contribution to journal › Article › peer-review

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title = "Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study",

abstract = "We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.",

keywords = "Cyproterone acetate, Danazol, Endometrium",

author = "Maurizio Marchini and Luigi Fedele and Stefano Bianchi and Luisa Arcaini and Diana Brioschi and {Di Nola}, Giuliana",

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AU - Marchini, Maurizio

AU - Fedele, Luigi

AU - Bianchi, Stefano

AU - Arcaini, Luisa

AU - Brioschi, Diana

AU - Di Nola, Giuliana

PY - 1991/7/1

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N2 - We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.

AB - We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.

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Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study

Abstract

Keywords

ASJC Scopus subject areas

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