Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study

Maurizio Marchini, Luigi Fedele, Stefano Bianchi, Luisa Arcaini, Diana Brioschi, Giuliana Di Nola

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume40
Issue number2
DOIs
Publication statusPublished - Jul 1 1991

Keywords

  • Cyproterone acetate
  • Danazol
  • Endometrium

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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