Abstract
We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 137-143 |
| Number of pages | 7 |
| Journal | European Journal of Obstetrics and Gynecology and Reproductive Biology |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 1 1991 |
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Keywords
- Cyproterone acetate
- Danazol
- Endometrium
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis : structural and ultrastructural study. / Marchini, Maurizio; Fedele, Luigi; Bianchi, Stefano; Arcaini, Luisa; Brioschi, Diana; Di Nola, Giuliana.
In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 40, No. 2, 01.07.1991, p. 137-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis
T2 - structural and ultrastructural study
AU - Marchini, Maurizio
AU - Fedele, Luigi
AU - Bianchi, Stefano
AU - Arcaini, Luisa
AU - Brioschi, Diana
AU - Di Nola, Giuliana
PY - 1991/7/1
Y1 - 1991/7/1
N2 - We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.
AB - We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.
KW - Cyproterone acetate
KW - Danazol
KW - Endometrium
UR - http://www.scopus.com/inward/record.url?scp=0025832464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025832464&partnerID=8YFLogxK
U2 - 10.1016/0028-2243(91)90105-T
DO - 10.1016/0028-2243(91)90105-T
M3 - Article
C2 - 1830018
AN - SCOPUS:0025832464
VL - 40
SP - 137
EP - 143
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 2
ER -