Endometrial release of soluble intercellular adhesion molecule 1 and endometriosis: Relationship to the extent of the disease

Paola Viganò, Edgardo Somigliana, Barbara Gaffuri, Roberta Santorsola, Mauro Busacca, Mario Vignali

Research output: Contribution to journalArticle

Abstract

Objective: To relate endometrial release of the soluble form of intercellular adhesion molecule 1 with extent of endometriosis.Methods: Samples of endometrium were collected from 23 women with endometriosis. Soluble intercellular adhesion molecule 1 was quantified in conditioned medium from 48-hour endometrial stromal cell cultures with use of a specific enzyme-linked immunosorbent assay. Levels were correlated with revised American Society for Reproductive Medicine classification score for adhesions, implants, and cysts and total score; number of endometriotic implants; cyst diameter; and presence or absence of pelvic pain symptoms and previous surgical procedures for endometriosis.Results: Endometrial release of soluble intercellular adhesion molecule 1 directly correlated with number of implants (r = .64, P <.005) and score for implants (r = .61, P <.005). There was no significant correlation between levels of the soluble molecule and score for adhesions or total score. Soluble intercellular adhesion molecule 1 shed by endometrium did not correlate with the score for ovarian cysts, although an inverse relationship was found with ovarian cyst diameter (r = -0.52, P <.05). No differences were detected between women who had pelvic pain and those who did not and between those who had previous surgery for endometriosis and those who had not.Conclusion: The association between endometrial release of soluble intercellular adhesion molecule 1 and the number and score of endometriotic implants suggests that the molecule might be of value in evaluating spread potential of refluxed endometrium. Copyright (C) 2000 The American College of Obstetricians and Gynecologists.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalObstetrics and Gynecology
Volume95
Issue number1
DOIs
Publication statusPublished - Jan 2000

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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