Endometrioid carcinoma of the ovary: A retrospective analysis of 106 cases

Giuseppe Grosso, Francesco Raspagliesi, Gabriela Baiocchi, Emanuela Di Re, Maria Colavita, Luigi Cobellis

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Abstract

Aims and background: This report retrospectively analyzes 105 cases of endometrioid carcinoma of the ovary treated at the National Cancer Institute of Milan from 1974 through December 1993. In 12 of the 106 cases (11.3%) a synchronous carcinoma of the uterine body was observed. Methods and study design: Only patients who had previously untreated disease were included in the study. Patients with synchronous tumors were staged according to their ovarian cancer and treated according to the stage of that disease. Results: Thirty-nine patients (36.8%) had stage I, 17 (16.0%) stage II, 43 (40.6%) stage III, and 7 (6.6%) stage IV disease. Moderately plus poorly differentiated tumors were present in 76 of the 106 cases (71.7%). Considering the 67 patients with advanced disease, residual tumor was absent in 27 cases (40.3%), ≤ 2 cm in 17 (25.4%), and > 2 cm in 23 (34.3%) cases. Systematic pelvic and para-aortic lymphadenectomy was performed in 60 patients (56.6%); selective sampling was carried out in 23 cases (21.7%). After surgery, 77 patients underwent various chemotherapy regimens. Conclusion: Using univariate analysis, FIGO stage, tumor grade, residual disease after surgery, lymph node status, and platinum in the chemotherapy regimen significantly influenced 5-year survival. However, when all these variables were included in a multivariate analysis only FIGO stage still had a significant impact on survival. Survival analysis also showed a trend towards longer survival in patients with synchronous tumors.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalTumori
Volume84
Issue number5
Publication statusPublished - 1998

Keywords

  • Endometrioid ovarian cancer
  • Ovarian cancer
  • Synchronous carcinoma

ASJC Scopus subject areas

  • Cancer Research

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    Grosso, G., Raspagliesi, F., Baiocchi, G., Di Re, E., Colavita, M., & Cobellis, L. (1998). Endometrioid carcinoma of the ovary: A retrospective analysis of 106 cases. Tumori, 84(5), 552-557.