Endometriosis and perceived stress: Impact of surgical and medical treatment

Lucia Lazzeri, Cinzia Orlandini, Silvia Vannuccini, Serena Pinzauti, Claudia Tosti, Errico Zupi, Rosella Elena Nappi, Felice Petraglia

Research output: Contribution to journalArticlepeer-review


Background: The aim of the study was to investigate the levels of perceived stress in a group of women with a long-term history of endometriosis in conjunction with surgical and/or medical treatments. Methods: A clinical trial was conducted at the Department of Molecular and Developmental Medicine, University of Siena, in collaboration with a non-profit association of women with endometriosis, A.P.E. Onlus. Patients (n = 204) with a previous diagnosis of endometriosis (for at least 3 years) were included in this study. Each patient completed a semi-structured questionnaire and a validated scale to assess perceived stress, the Perceived Stress Scale (PSS) by e-mail. Results: The study showed that in women with a long-term history of endometriosis, the level of perceived stress was increased by repeated surgical treatments and reduced by some medical treatments. The median PSS value was 23 (range 9-36) and 30.6% of the study population were included in the highest stress category (>26). The highest levels were found in patients who had undergone the most surgery. The use of progestins was associated with a lower perceived stress (p = 0.004) than in the patients treated with gonadotropin-releasing hormones. Conclusions: Long-term endometriosis has a relevant impact on perceived stress, in particular in those undergoing repeated surgery.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalGynecologic and Obstetric Investigation
Issue number4
Publication statusPublished - May 28 2015


  • Endometriosis
  • Perceived stress
  • Surgery

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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