Endometriosis-associated clear cell carcinoma of the abdominal wall after caesarean section: A case report and review of the literature

Luca Giannella, Matteo Serri, Elena Maccaroni, Jacopo Di Giuseppe, Giovanni Delli Carpini, Rossana Berardi, Francesco Sopracordevole, Andrea Ciavattini

Research output: Contribution to journalArticlepeer-review


Background/Aim: Clear cell carcinoma of the abdominal wall is a sporadic event. To date, about thirty cases have been reported in the literature. This article provides a case report and literature review of an infrequent occurrence with poor prognosis. Case Report: A 45-year-old woman with pelvic pain and an abdominal mass came to our attention. Her medical history was notable for two previous cesarean sections. Physical examination revealed a smooth, multilocular mass measuring about 20 cm, arising from the previous surgical scar. Histology revealed clear-cell carcinoma resulting from the transformation of abdominal wall endometriosis. Given the disease extent, the patient underwent front-line chemotherapy. After several and multiple chemotherapy regimens, there was a disease progression that resulted in the death of the patient in 7 months. The literature review showed that a previous cesarean section was present in 91% of cases. Besides, approximately 26.5% of women died within 12 months of being diagnosed. The mean age of women was 45.88 years, while the average size of the lesion was 11 cm. Conclusion: Clear cell carcinoma is a rare but occurring event. Middleaged women showing an abdominal wall mass in close relation with a surgical scar from a previous cesarean section must be promptly investigated. Treatment options usually include surgery and chemotherapy with poor results.

Original languageEnglish
Pages (from-to)2147-2152
Number of pages6
JournalIn Vivo
Issue number4
Publication statusPublished - Aug 2020


  • Abdominal wall endometriosis
  • Cesarean scar endometriosis
  • Chemotherapy
  • Clear cell carcinoma
  • Endometriosis
  • Surgery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology


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