Endometriosis: What a pain it is

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The contrasting findings obtained in the studies that have attempted to correlate the stage of endometriosis with severity of pain symptoms suggest that some specific characteristics of the lesions are more implicated in the genesis of pain than disease extension per se. Thus, fresh, metabolically active, intraperitoneal implants may cause functional pain symptoms such as dysmenorrhea, whereas infiltrating, nodular and fibrotic lesions are responsible for organic-type pain such as deep dyspareunia. Women with symptomatic endometriosis seem to have reduced peripheral β-endorphin production in comparison with pain patients without the disease, although neuroendocrine modulation of pelvic nociceptive stimuli is far from clear. There is little evidence to support the notion that specific psychiatric features render some women more vulnerable to developing endometriosis, as results from investigations performed on women with asymptomatic lesions are very similar to normative data. Moreover, it appears that the psychological profile of symptomatic patients with the disease is no different from those with pain and a normal pelvis or other gynecological conditions. Consequently, the local biochemical and physical effects of lesions seem to be the most important factors in determining frequency and severity of symptoms.

Original languageEnglish
Pages (from-to)251-261
Number of pages11
JournalSeminars in Reproductive Endocrinology
Volume15
Issue number3
Publication statusPublished - 1997

Fingerprint

Endometriosis
Pain
Endorphins
Dyspareunia
Dysmenorrhea
Pelvis
Psychiatry
Psychology

Keywords

  • Dysmenorrhea
  • Dyspareunia
  • Endometriosis
  • Laparoscopy
  • Pelvic pain

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Reproductive Medicine

Cite this

Endometriosis : What a pain it is. / Vercellini, Paolo.

In: Seminars in Reproductive Endocrinology, Vol. 15, No. 3, 1997, p. 251-261.

Research output: Contribution to journalArticle

@article{3ac527079640402cac7f1a8a493173b0,
title = "Endometriosis: What a pain it is",
abstract = "The contrasting findings obtained in the studies that have attempted to correlate the stage of endometriosis with severity of pain symptoms suggest that some specific characteristics of the lesions are more implicated in the genesis of pain than disease extension per se. Thus, fresh, metabolically active, intraperitoneal implants may cause functional pain symptoms such as dysmenorrhea, whereas infiltrating, nodular and fibrotic lesions are responsible for organic-type pain such as deep dyspareunia. Women with symptomatic endometriosis seem to have reduced peripheral β-endorphin production in comparison with pain patients without the disease, although neuroendocrine modulation of pelvic nociceptive stimuli is far from clear. There is little evidence to support the notion that specific psychiatric features render some women more vulnerable to developing endometriosis, as results from investigations performed on women with asymptomatic lesions are very similar to normative data. Moreover, it appears that the psychological profile of symptomatic patients with the disease is no different from those with pain and a normal pelvis or other gynecological conditions. Consequently, the local biochemical and physical effects of lesions seem to be the most important factors in determining frequency and severity of symptoms.",
keywords = "Dysmenorrhea, Dyspareunia, Endometriosis, Laparoscopy, Pelvic pain",
author = "Paolo Vercellini",
year = "1997",
language = "English",
volume = "15",
pages = "251--261",
journal = "Seminars in Reproductive Endocrinology",
issn = "0734-8630",
publisher = "Thieme Medical Publishers",
number = "3",

}

TY - JOUR

T1 - Endometriosis

T2 - What a pain it is

AU - Vercellini, Paolo

PY - 1997

Y1 - 1997

N2 - The contrasting findings obtained in the studies that have attempted to correlate the stage of endometriosis with severity of pain symptoms suggest that some specific characteristics of the lesions are more implicated in the genesis of pain than disease extension per se. Thus, fresh, metabolically active, intraperitoneal implants may cause functional pain symptoms such as dysmenorrhea, whereas infiltrating, nodular and fibrotic lesions are responsible for organic-type pain such as deep dyspareunia. Women with symptomatic endometriosis seem to have reduced peripheral β-endorphin production in comparison with pain patients without the disease, although neuroendocrine modulation of pelvic nociceptive stimuli is far from clear. There is little evidence to support the notion that specific psychiatric features render some women more vulnerable to developing endometriosis, as results from investigations performed on women with asymptomatic lesions are very similar to normative data. Moreover, it appears that the psychological profile of symptomatic patients with the disease is no different from those with pain and a normal pelvis or other gynecological conditions. Consequently, the local biochemical and physical effects of lesions seem to be the most important factors in determining frequency and severity of symptoms.

AB - The contrasting findings obtained in the studies that have attempted to correlate the stage of endometriosis with severity of pain symptoms suggest that some specific characteristics of the lesions are more implicated in the genesis of pain than disease extension per se. Thus, fresh, metabolically active, intraperitoneal implants may cause functional pain symptoms such as dysmenorrhea, whereas infiltrating, nodular and fibrotic lesions are responsible for organic-type pain such as deep dyspareunia. Women with symptomatic endometriosis seem to have reduced peripheral β-endorphin production in comparison with pain patients without the disease, although neuroendocrine modulation of pelvic nociceptive stimuli is far from clear. There is little evidence to support the notion that specific psychiatric features render some women more vulnerable to developing endometriosis, as results from investigations performed on women with asymptomatic lesions are very similar to normative data. Moreover, it appears that the psychological profile of symptomatic patients with the disease is no different from those with pain and a normal pelvis or other gynecological conditions. Consequently, the local biochemical and physical effects of lesions seem to be the most important factors in determining frequency and severity of symptoms.

KW - Dysmenorrhea

KW - Dyspareunia

KW - Endometriosis

KW - Laparoscopy

KW - Pelvic pain

UR - http://www.scopus.com/inward/record.url?scp=0030696162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030696162&partnerID=8YFLogxK

M3 - Article

C2 - 9383834

AN - SCOPUS:0030696162

VL - 15

SP - 251

EP - 261

JO - Seminars in Reproductive Endocrinology

JF - Seminars in Reproductive Endocrinology

SN - 0734-8630

IS - 3

ER -