Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation

Laura Benaglia, Edgardo Somigliana, Paolo Vercellini, Annalisa Abbiati, Guido Ragni, Luigi Fedele

Research output: Contribution to journalArticlepeer-review


BACKGROUND: A growing body of evidence suggests that ovarian reserve is damaged after excision of ovarian endometriomas. However, it may not be excluded that gonadal damage is at least partly caused by the very presence of an endometrioma per se, thus preceding surgery. To clarify this aspect, we set up a prospective study in women with monolateral endometriomas in order to assess the rate of ovulation in affected ovaries. MATERIALS AND METHODS: Seventy women with monolateral endometriomas who had not undergone previous adnexal surgery underwent serial ecographic examinations to determine the side of ovulation. RESULTS: Ovulation occurred in the affected ovary in 22 cases (31%; 95% CI: 22-43%). Assuming that the expected rate of ovulation in both ovaries in healthy women is similar, this difference is statistically significant (P = 0.002). CONCLUSION: The physiological mechanisms leading to ovulation are deranged in ovaries with endometriomas.

Original languageEnglish
Pages (from-to)2183-2186
Number of pages4
JournalHuman Reproduction
Issue number9
Publication statusPublished - Sep 2009


  • Endometrioma
  • Endometriosis
  • Ovulation

ASJC Scopus subject areas

  • Rehabilitation
  • Obstetrics and Gynaecology
  • Reproductive Medicine


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