Amiodarone, a highly effective antiarrhythmic agent, accumulates in different tissues, causing a variety of adverse effects.1-3 Long-term amiodarone treatment may cause diffuse interstitial pulmonary fibrosis and inflammation, with accumulation of cytoplasmic bodies containing electron-dense lamellas in pneumyocytes and alveolar macrophages1,2. Similar bodies have been described in liver, lymph nodes, blood leukocytes, cornea, endothelial cells of skin, colonie mucosa,3 and Schwann cells. Such bodies also have been found in cardiac myocytes of experimental animals treated with multiple doses of this drug4,5; however, to our knowledge, they have not been reported in the myocardium of patients treated with amiodarone. This report describes ultrastructural changes in the myocardium of 2 patients with idiopathic dilated cardiomyopathy who had received long-term amiodarone treatment.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine