Endomyocardial biopsy of normal donor hearts before cardiac transplantation: A morphological and morphometrical study in 97 cases

E. Arbustini, R. Pozzi, M. Grasso, C. Campana, L. Martinelli, C. Montemartini, A. Gavazzi, A. Pucci, M. Diegoli, G. Graziano, C. Goggi, M. Vigano

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Abstract

Endomyocardial biopsies from 97 normal donor hearts were examined. Morphometric analysis showed: mean myocyte diameter 22.21±6.93 μ, mean nuclear dimension 7.32±2.33 μ, mean nuclear/sarcoplasmic ratio 0.33±0.02. 31 biopsies showed enlarged myocytes (mean diameter 31.65±3.98 μ) with increased nuclear size (mean 10.45±1.39 μ), but preserved nuclear/sarcoplasmic ratio (mean 0.33±0.01). The mean age of these latter subjects was significantly higher. Endocardial thickness mean value was 17.73±4.58 μ, but in 28 cases the value exceeded the considered upper normal limit of 20 μ. Interstitial mononuclear cells were rare and randomly present. Interstitial fibrosis was observed in 15% and focal fibrosis in 27% of cases. Our results show that histology of biopsies from clinically normal hearts can widely vary, sometime overriding the pathologic boundaries. These apparently 'benign' abnormalities should be kept in mind when specific pathologic substrates of cardiac diseases have to be defined.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalAmerican Journal of Cardiovascular Pathology
Volume4
Issue number1
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

Cite this

Arbustini, E., Pozzi, R., Grasso, M., Campana, C., Martinelli, L., Montemartini, C., Gavazzi, A., Pucci, A., Diegoli, M., Graziano, G., Goggi, C., & Vigano, M. (1992). Endomyocardial biopsy of normal donor hearts before cardiac transplantation: A morphological and morphometrical study in 97 cases. American Journal of Cardiovascular Pathology, 4(1), 1-8.