TY - JOUR
T1 - Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis
AU - Ferrari, D.
AU - Pinton, P.
AU - Szabadkai, G.
AU - Chami, M.
AU - Campanella, M.
AU - Pozzan, T.
AU - Rizzuto, Rosario
PY - 2002/11
Y1 - 2002/11
N2 - In the complex signalling interplay that allows extracellular signals to be decoded into activation of apoptotic cell death, Ca2+ plays a significant role. This is supported not only by evidence linking alterations in Ca2+ homeostasis to the triggering of apoptotic (and in some cases necrotic) cell death, but also by recent data indicating that a key anti-apoptotic protein, Bcl-2, has a direct effect on ER Ca2+ handling. We will briefly summarise the first aspect, and describe in more detail these new data, demonstrating that (i) Bcl-2 reduces the state of filling of the ER Ca2+ store and (ii) this Ca2+ signalling alteration renders the cells less sensitive to apoptotic stimuli. Overall, these results suggest that calcium homeostasis may represent a pharmacological target in the fundamental pathological process of apoptosis.
AB - In the complex signalling interplay that allows extracellular signals to be decoded into activation of apoptotic cell death, Ca2+ plays a significant role. This is supported not only by evidence linking alterations in Ca2+ homeostasis to the triggering of apoptotic (and in some cases necrotic) cell death, but also by recent data indicating that a key anti-apoptotic protein, Bcl-2, has a direct effect on ER Ca2+ handling. We will briefly summarise the first aspect, and describe in more detail these new data, demonstrating that (i) Bcl-2 reduces the state of filling of the ER Ca2+ store and (ii) this Ca2+ signalling alteration renders the cells less sensitive to apoptotic stimuli. Overall, these results suggest that calcium homeostasis may represent a pharmacological target in the fundamental pathological process of apoptosis.
UR - http://www.scopus.com/inward/record.url?scp=0036878819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036878819&partnerID=8YFLogxK
U2 - 10.1016/S0143416002002014
DO - 10.1016/S0143416002002014
M3 - Article
C2 - 12543100
AN - SCOPUS:0036878819
VL - 32
SP - 413
EP - 420
JO - Cell Calcium
JF - Cell Calcium
SN - 0143-4160
IS - 5-6
ER -