Endoplasmic reticulum-Golgi complex membrane contact sites

Maria Antonietta De Matteis; Laura Rita Rega

doi:10.1016/j.ceb.2015.04.001

Endoplasmic reticulum-Golgi complex membrane contact sites

Maria Antonietta De Matteis, Laura Rita Rega

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article

Abstract

Although they were identified as long ago as the 1960s, there are still many unknowns regarding the functions and composition of membrane contact sites between the endoplasmic reticulum (ER) and the trans-Golgi (TG). While it seems to be fairly well established that they facilitate lipid exchange between the two organelles, much less is known about how they are regulated. A bottleneck in the study of the ER-TG contact sites has been the absence of methods for their biochemical isolation and visualization by light microscopy. Herein we provide an overview of current knowledge about ER-TG contact sites with a particular emphasis on the questions that remain to be explored.

Original language	English
Pages (from-to)	43-50
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	35
DOIs	https://doi.org/10.1016/j.ceb.2015.04.001
Publication status	Published - Aug 1 2015

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ASJC Scopus subject areas

Cell Biology
Medicine(all)

Cite this

De Matteis, M. A., & Rega, L. R. (2015). Endoplasmic reticulum-Golgi complex membrane contact sites. Current Opinion in Cell Biology, 35, 43-50. https://doi.org/10.1016/j.ceb.2015.04.001

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Access to Document

10.1016/j.ceb.2015.04.001