Endoplasmic reticulum stress and the making of a professional secretory cell

Eelco Van Anken, Ineke Braakman

Research output: Contribution to journalArticlepeer-review


Homeostasis of the protein folding machinery in the endoplasmic reticulum (ER) is maintained via several parallel unfolded protein response pathways that are remarkably conserved from yeast to man. Together, these pathways are integrated into a complex circuitry that can be modulated in various ways, not only to cope with various stress conditions, but also to fine-tune the capacity of the ER folding machinery when precursor cells differentiate into professional secretory cells.

Original languageEnglish
Pages (from-to)269-283
Number of pages15
JournalCritical Reviews in Biochemistry and Molecular Biology
Issue number5
Publication statusPublished - Sep 1 2005


  • ATF4
  • ATF6
  • ERAD
  • Ire1
  • PERK
  • UPR
  • XBP-1

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry


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