Endorcine cells producing regulatory peptides

E. Solcia, L. Usellini, R. Buffa, G. Rindi, L. Villani, C. Zampatti, E. Silini

Research output: Contribution to journalArticle

Abstract

Recent data on the immunologication of regulatory peptides and related propeptide sequences in endocrine cells and tumours of the gastrointestinal tract pancreas, lung, thyroid, pituitary (ACTH and opioids), adrenals and paraganglia have been revised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory beenrevised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory polypeptide), neurotensin, glicentin/glucagon-37 and PYY (peptide tyrosine tyrosine) are the main products of gastrointestinal endocrine cells; glucagon, CRF (corticotropin releasing factor), somatostatin, PP (pancreatic polypeptide) and GRF (growth hormone releasing factor), in addition to insulin, are produced in pancreatic islet cells; bombesin-related peptidesare the main markers of pulmonary endocrine cells; calcitonin and CGRP (calcitonin gene-related peptide) occur in thyroid and extrathyroid C cells; ACTH and endorphins in anterior and intermediate lobe pituitary cells, α-MSH and CLIP (corticotropoin-like intermediate lobe peptide) in intermediate lobe cells; met- and leu-enkephalins and related peptides in adrenal medullary and paraganglionic cells as well as in some gut (enterochromaffin) cells; NPY (neuropeptide Y) in adrenalin-type adrenal medullary cells, etc.. Both tissue-appropriate and tissue-inappropriate regulatory peptides are produced by endocrine tumours, with inappropriate peptides mostly produced by malignant tumours.

Original languageEnglish
Pages (from-to)839-850
Number of pages12
JournalExperientia
Volume43
Issue number7
DOIs
Publication statusPublished - Jul 1987

Fingerprint

xenopsin
Peptides
Somatostatin
Gastric Inhibitory Polypeptide
Motilin
Tumors
Secretin
Endocrine Cells
Cholecystokinin
Gastrins
Cells
Glucagon
Islets of Langerhans
tyrosyltyrosine
Adrenocorticotropic Hormone
Glicentin
Thyroid Gland
Intermediate Pituitary Gland
Enterochromaffin Cells
Enteroendocrine Cells

Keywords

  • ACTH
  • Bombesin
  • calcitonin
  • CCK
  • CRF
  • endocrine cells
  • endocrine tumours
  • gastrin
  • GIP
  • glucagon
  • GRF
  • motilin
  • neurotensin
  • opioids
  • PP
  • secretin
  • somatostatin
  • substance P

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Solcia, E., Usellini, L., Buffa, R., Rindi, G., Villani, L., Zampatti, C., & Silini, E. (1987). Endorcine cells producing regulatory peptides. Experientia, 43(7), 839-850. https://doi.org/10.1007/BF01945362

Endorcine cells producing regulatory peptides. / Solcia, E.; Usellini, L.; Buffa, R.; Rindi, G.; Villani, L.; Zampatti, C.; Silini, E.

In: Experientia, Vol. 43, No. 7, 07.1987, p. 839-850.

Research output: Contribution to journalArticle

Solcia, E, Usellini, L, Buffa, R, Rindi, G, Villani, L, Zampatti, C & Silini, E 1987, 'Endorcine cells producing regulatory peptides', Experientia, vol. 43, no. 7, pp. 839-850. https://doi.org/10.1007/BF01945362
Solcia E, Usellini L, Buffa R, Rindi G, Villani L, Zampatti C et al. Endorcine cells producing regulatory peptides. Experientia. 1987 Jul;43(7):839-850. https://doi.org/10.1007/BF01945362
Solcia, E. ; Usellini, L. ; Buffa, R. ; Rindi, G. ; Villani, L. ; Zampatti, C. ; Silini, E. / Endorcine cells producing regulatory peptides. In: Experientia. 1987 ; Vol. 43, No. 7. pp. 839-850.
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