Endoscopic resection for superficial colorectal neoplasia in Italy

A prospective multicentre study

Livio Cipolletta, Gianluca Rotondano, Maria A. Bianco, Federico Buffoli, Giuseppe Gizzi, Francesco Tessari, M. Gentile, F. Spirito, L. De Luca, D. Baroncini, R. Sassatelli, V. Iori, O. Tarantino, M. Biagini, G. Manes, S. Pallotta, R. Briglia, F. Praianò, F. Buffoli, E. Iiritano & 80 others L. Buri, F. Tonello, R. Cestari, G. Lancini, S. Sansone, F. Cipolletta, O. Ignomirelli, M. Ciuffi, G. Coccia, A. Allegretti, L. Petruzziello, P. Cesaro, G. Costamagna, L. M. Montalbano, M. Giunta, L. Corazza, G. De Maio, M. Del Piano, M. Orsello, P. Di Giorgio, F. Giannattasio, E. Di Giulio, S. Angeletti, A. Pisani, A. Di Leo, G. Di Matteo, P. Giorgio, R. Frego, M. Dinelli, L. Familiari, S. Pallio, L. Ficano, D. Ligresti, P. Parisi, S. Astretto, B. Germanà, L. G. Cavallaro, S. Rodinò, N. Saccà, G. Gizzi, V. Villani, M. Ingrosso, S. Marangi, M. Delle Cave, G. Sarran-tonio, P. Loriga, G. Asnaghi, A. Manca, E. Masci, P. Viaggi, O. Labianca, S. Morini, R. Lorenzetti, A. Milano, F. Laterza, G. Del Vecchio Blanco, M. Coppola, F. Parente, S. Bargiggia, P. Cesari, C. Petruzzellis, C. Widmeyer, E. Cavargini, E. Ricci, M. Giovanardi, F. Santilli, G. Scaglione, I. Sorrentini, M. Silla, A. Spadaccini, M. De Bellis, G. B. Rossi, A. Amato, V. Terlizzi, M. Silvestrelli, L. M. Tomarelli, G. Feliciangeli, A. Zambelli, G. Manfredi, R. Marmo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients. Methods: Prospective multicentre assessment of resection of sessile polyps or non-polypoid lesions ≥ 10. mm in size or smaller (if depressed). Outcome measures included complete excision, morbidity, mortality, and residual/recurrence at 12 months. Results: Overall, 1012 resections in 928 patients were analysed (62.4% sessile polyps, 28.8% laterally spreading tumours, 8.7% depressed non-polypoid lesions). Lesions were prevalent in the proximal colon. Enbloc resection was possible in 715/1012 cases (70.7%), whereas piecemeal resection was required in 297 (29.3%). Endoscopically complete excision was achieved in 866 cases (85.6%). Adverse events occurred in 83 (8.2%), and no deaths occurred. Independent predictors of 12-month residual/recurrence were the location of the lesion in the proximal colon (OR 2.22 [95% CI 1.16-4.26]; p= 0.015) and piecemeal endoscopic resection (OR 2.76 [95% CI 1.56-4.87]; p= 0.0005). Limitations of the study were: potential expertise bias, no data on eligible and potentially resectable excluded lesions, high percentage of lesions <20. mm, follow-up limited to 1 year. Conclusion: In this registry study the endoscopic resection of colorectal lesions was safe and achieved high rates of long-term endoscopic clearance.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalDigestive and Liver Disease
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Polyps
Italy
Multicenter Studies
Colon
Prospective Studies
Recurrence
Registries
Neoplasms
Outcome Assessment (Health Care)
Morbidity
Safety
Mortality

Keywords

  • Adverse events
  • Colorectal neoplasia
  • Endoscopic resection
  • Mucosectomy
  • Outcomes

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Cipolletta, L., Rotondano, G., Bianco, M. A., Buffoli, F., Gizzi, G., Tessari, F., ... Marmo, R. (2014). Endoscopic resection for superficial colorectal neoplasia in Italy: A prospective multicentre study. Digestive and Liver Disease, 46(2), 146-151. https://doi.org/10.1016/j.dld.2013.09.019

Endoscopic resection for superficial colorectal neoplasia in Italy : A prospective multicentre study. / Cipolletta, Livio; Rotondano, Gianluca; Bianco, Maria A.; Buffoli, Federico; Gizzi, Giuseppe; Tessari, Francesco; Gentile, M.; Spirito, F.; De Luca, L.; Baroncini, D.; Sassatelli, R.; Iori, V.; Tarantino, O.; Biagini, M.; Manes, G.; Pallotta, S.; Briglia, R.; Praianò, F.; Buffoli, F.; Iiritano, E.; Buri, L.; Tonello, F.; Cestari, R.; Lancini, G.; Sansone, S.; Cipolletta, F.; Ignomirelli, O.; Ciuffi, M.; Coccia, G.; Allegretti, A.; Petruzziello, L.; Cesaro, P.; Costamagna, G.; Montalbano, L. M.; Giunta, M.; Corazza, L.; De Maio, G.; Del Piano, M.; Orsello, M.; Di Giorgio, P.; Giannattasio, F.; Di Giulio, E.; Angeletti, S.; Pisani, A.; Di Leo, A.; Di Matteo, G.; Giorgio, P.; Frego, R.; Dinelli, M.; Familiari, L.; Pallio, S.; Ficano, L.; Ligresti, D.; Parisi, P.; Astretto, S.; Germanà, B.; Cavallaro, L. G.; Rodinò, S.; Saccà, N.; Gizzi, G.; Villani, V.; Ingrosso, M.; Marangi, S.; Delle Cave, M.; Sarran-tonio, G.; Loriga, P.; Asnaghi, G.; Manca, A.; Masci, E.; Viaggi, P.; Labianca, O.; Morini, S.; Lorenzetti, R.; Milano, A.; Laterza, F.; Del Vecchio Blanco, G.; Coppola, M.; Parente, F.; Bargiggia, S.; Cesari, P.; Petruzzellis, C.; Widmeyer, C.; Cavargini, E.; Ricci, E.; Giovanardi, M.; Santilli, F.; Scaglione, G.; Sorrentini, I.; Silla, M.; Spadaccini, A.; De Bellis, M.; Rossi, G. B.; Amato, A.; Terlizzi, V.; Silvestrelli, M.; Tomarelli, L. M.; Feliciangeli, G.; Zambelli, A.; Manfredi, G.; Marmo, R.

In: Digestive and Liver Disease, Vol. 46, No. 2, 02.2014, p. 146-151.

Research output: Contribution to journalArticle

Cipolletta, L, Rotondano, G, Bianco, MA, Buffoli, F, Gizzi, G, Tessari, F, Gentile, M, Spirito, F, De Luca, L, Baroncini, D, Sassatelli, R, Iori, V, Tarantino, O, Biagini, M, Manes, G, Pallotta, S, Briglia, R, Praianò, F, Buffoli, F, Iiritano, E, Buri, L, Tonello, F, Cestari, R, Lancini, G, Sansone, S, Cipolletta, F, Ignomirelli, O, Ciuffi, M, Coccia, G, Allegretti, A, Petruzziello, L, Cesaro, P, Costamagna, G, Montalbano, LM, Giunta, M, Corazza, L, De Maio, G, Del Piano, M, Orsello, M, Di Giorgio, P, Giannattasio, F, Di Giulio, E, Angeletti, S, Pisani, A, Di Leo, A, Di Matteo, G, Giorgio, P, Frego, R, Dinelli, M, Familiari, L, Pallio, S, Ficano, L, Ligresti, D, Parisi, P, Astretto, S, Germanà, B, Cavallaro, LG, Rodinò, S, Saccà, N, Gizzi, G, Villani, V, Ingrosso, M, Marangi, S, Delle Cave, M, Sarran-tonio, G, Loriga, P, Asnaghi, G, Manca, A, Masci, E, Viaggi, P, Labianca, O, Morini, S, Lorenzetti, R, Milano, A, Laterza, F, Del Vecchio Blanco, G, Coppola, M, Parente, F, Bargiggia, S, Cesari, P, Petruzzellis, C, Widmeyer, C, Cavargini, E, Ricci, E, Giovanardi, M, Santilli, F, Scaglione, G, Sorrentini, I, Silla, M, Spadaccini, A, De Bellis, M, Rossi, GB, Amato, A, Terlizzi, V, Silvestrelli, M, Tomarelli, LM, Feliciangeli, G, Zambelli, A, Manfredi, G & Marmo, R 2014, 'Endoscopic resection for superficial colorectal neoplasia in Italy: A prospective multicentre study', Digestive and Liver Disease, vol. 46, no. 2, pp. 146-151. https://doi.org/10.1016/j.dld.2013.09.019
Cipolletta, Livio ; Rotondano, Gianluca ; Bianco, Maria A. ; Buffoli, Federico ; Gizzi, Giuseppe ; Tessari, Francesco ; Gentile, M. ; Spirito, F. ; De Luca, L. ; Baroncini, D. ; Sassatelli, R. ; Iori, V. ; Tarantino, O. ; Biagini, M. ; Manes, G. ; Pallotta, S. ; Briglia, R. ; Praianò, F. ; Buffoli, F. ; Iiritano, E. ; Buri, L. ; Tonello, F. ; Cestari, R. ; Lancini, G. ; Sansone, S. ; Cipolletta, F. ; Ignomirelli, O. ; Ciuffi, M. ; Coccia, G. ; Allegretti, A. ; Petruzziello, L. ; Cesaro, P. ; Costamagna, G. ; Montalbano, L. M. ; Giunta, M. ; Corazza, L. ; De Maio, G. ; Del Piano, M. ; Orsello, M. ; Di Giorgio, P. ; Giannattasio, F. ; Di Giulio, E. ; Angeletti, S. ; Pisani, A. ; Di Leo, A. ; Di Matteo, G. ; Giorgio, P. ; Frego, R. ; Dinelli, M. ; Familiari, L. ; Pallio, S. ; Ficano, L. ; Ligresti, D. ; Parisi, P. ; Astretto, S. ; Germanà, B. ; Cavallaro, L. G. ; Rodinò, S. ; Saccà, N. ; Gizzi, G. ; Villani, V. ; Ingrosso, M. ; Marangi, S. ; Delle Cave, M. ; Sarran-tonio, G. ; Loriga, P. ; Asnaghi, G. ; Manca, A. ; Masci, E. ; Viaggi, P. ; Labianca, O. ; Morini, S. ; Lorenzetti, R. ; Milano, A. ; Laterza, F. ; Del Vecchio Blanco, G. ; Coppola, M. ; Parente, F. ; Bargiggia, S. ; Cesari, P. ; Petruzzellis, C. ; Widmeyer, C. ; Cavargini, E. ; Ricci, E. ; Giovanardi, M. ; Santilli, F. ; Scaglione, G. ; Sorrentini, I. ; Silla, M. ; Spadaccini, A. ; De Bellis, M. ; Rossi, G. B. ; Amato, A. ; Terlizzi, V. ; Silvestrelli, M. ; Tomarelli, L. M. ; Feliciangeli, G. ; Zambelli, A. ; Manfredi, G. ; Marmo, R. / Endoscopic resection for superficial colorectal neoplasia in Italy : A prospective multicentre study. In: Digestive and Liver Disease. 2014 ; Vol. 46, No. 2. pp. 146-151.
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abstract = "Background: Since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients. Methods: Prospective multicentre assessment of resection of sessile polyps or non-polypoid lesions ≥ 10. mm in size or smaller (if depressed). Outcome measures included complete excision, morbidity, mortality, and residual/recurrence at 12 months. Results: Overall, 1012 resections in 928 patients were analysed (62.4{\%} sessile polyps, 28.8{\%} laterally spreading tumours, 8.7{\%} depressed non-polypoid lesions). Lesions were prevalent in the proximal colon. Enbloc resection was possible in 715/1012 cases (70.7{\%}), whereas piecemeal resection was required in 297 (29.3{\%}). Endoscopically complete excision was achieved in 866 cases (85.6{\%}). Adverse events occurred in 83 (8.2{\%}), and no deaths occurred. Independent predictors of 12-month residual/recurrence were the location of the lesion in the proximal colon (OR 2.22 [95{\%} CI 1.16-4.26]; p= 0.015) and piecemeal endoscopic resection (OR 2.76 [95{\%} CI 1.56-4.87]; p= 0.0005). Limitations of the study were: potential expertise bias, no data on eligible and potentially resectable excluded lesions, high percentage of lesions <20. mm, follow-up limited to 1 year. Conclusion: In this registry study the endoscopic resection of colorectal lesions was safe and achieved high rates of long-term endoscopic clearance.",
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TY - JOUR

T1 - Endoscopic resection for superficial colorectal neoplasia in Italy

T2 - A prospective multicentre study

AU - Cipolletta, Livio

AU - Rotondano, Gianluca

AU - Bianco, Maria A.

AU - Buffoli, Federico

AU - Gizzi, Giuseppe

AU - Tessari, Francesco

AU - Gentile, M.

AU - Spirito, F.

AU - De Luca, L.

AU - Baroncini, D.

AU - Sassatelli, R.

AU - Iori, V.

AU - Tarantino, O.

AU - Biagini, M.

AU - Manes, G.

AU - Pallotta, S.

AU - Briglia, R.

AU - Praianò, F.

AU - Buffoli, F.

AU - Iiritano, E.

AU - Buri, L.

AU - Tonello, F.

AU - Cestari, R.

AU - Lancini, G.

AU - Sansone, S.

AU - Cipolletta, F.

AU - Ignomirelli, O.

AU - Ciuffi, M.

AU - Coccia, G.

AU - Allegretti, A.

AU - Petruzziello, L.

AU - Cesaro, P.

AU - Costamagna, G.

AU - Montalbano, L. M.

AU - Giunta, M.

AU - Corazza, L.

AU - De Maio, G.

AU - Del Piano, M.

AU - Orsello, M.

AU - Di Giorgio, P.

AU - Giannattasio, F.

AU - Di Giulio, E.

AU - Angeletti, S.

AU - Pisani, A.

AU - Di Leo, A.

AU - Di Matteo, G.

AU - Giorgio, P.

AU - Frego, R.

AU - Dinelli, M.

AU - Familiari, L.

AU - Pallio, S.

AU - Ficano, L.

AU - Ligresti, D.

AU - Parisi, P.

AU - Astretto, S.

AU - Germanà, B.

AU - Cavallaro, L. G.

AU - Rodinò, S.

AU - Saccà, N.

AU - Gizzi, G.

AU - Villani, V.

AU - Ingrosso, M.

AU - Marangi, S.

AU - Delle Cave, M.

AU - Sarran-tonio, G.

AU - Loriga, P.

AU - Asnaghi, G.

AU - Manca, A.

AU - Masci, E.

AU - Viaggi, P.

AU - Labianca, O.

AU - Morini, S.

AU - Lorenzetti, R.

AU - Milano, A.

AU - Laterza, F.

AU - Del Vecchio Blanco, G.

AU - Coppola, M.

AU - Parente, F.

AU - Bargiggia, S.

AU - Cesari, P.

AU - Petruzzellis, C.

AU - Widmeyer, C.

AU - Cavargini, E.

AU - Ricci, E.

AU - Giovanardi, M.

AU - Santilli, F.

AU - Scaglione, G.

AU - Sorrentini, I.

AU - Silla, M.

AU - Spadaccini, A.

AU - De Bellis, M.

AU - Rossi, G. B.

AU - Amato, A.

AU - Terlizzi, V.

AU - Silvestrelli, M.

AU - Tomarelli, L. M.

AU - Feliciangeli, G.

AU - Zambelli, A.

AU - Manfredi, G.

AU - Marmo, R.

PY - 2014/2

Y1 - 2014/2

N2 - Background: Since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients. Methods: Prospective multicentre assessment of resection of sessile polyps or non-polypoid lesions ≥ 10. mm in size or smaller (if depressed). Outcome measures included complete excision, morbidity, mortality, and residual/recurrence at 12 months. Results: Overall, 1012 resections in 928 patients were analysed (62.4% sessile polyps, 28.8% laterally spreading tumours, 8.7% depressed non-polypoid lesions). Lesions were prevalent in the proximal colon. Enbloc resection was possible in 715/1012 cases (70.7%), whereas piecemeal resection was required in 297 (29.3%). Endoscopically complete excision was achieved in 866 cases (85.6%). Adverse events occurred in 83 (8.2%), and no deaths occurred. Independent predictors of 12-month residual/recurrence were the location of the lesion in the proximal colon (OR 2.22 [95% CI 1.16-4.26]; p= 0.015) and piecemeal endoscopic resection (OR 2.76 [95% CI 1.56-4.87]; p= 0.0005). Limitations of the study were: potential expertise bias, no data on eligible and potentially resectable excluded lesions, high percentage of lesions <20. mm, follow-up limited to 1 year. Conclusion: In this registry study the endoscopic resection of colorectal lesions was safe and achieved high rates of long-term endoscopic clearance.

AB - Background: Since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients. Methods: Prospective multicentre assessment of resection of sessile polyps or non-polypoid lesions ≥ 10. mm in size or smaller (if depressed). Outcome measures included complete excision, morbidity, mortality, and residual/recurrence at 12 months. Results: Overall, 1012 resections in 928 patients were analysed (62.4% sessile polyps, 28.8% laterally spreading tumours, 8.7% depressed non-polypoid lesions). Lesions were prevalent in the proximal colon. Enbloc resection was possible in 715/1012 cases (70.7%), whereas piecemeal resection was required in 297 (29.3%). Endoscopically complete excision was achieved in 866 cases (85.6%). Adverse events occurred in 83 (8.2%), and no deaths occurred. Independent predictors of 12-month residual/recurrence were the location of the lesion in the proximal colon (OR 2.22 [95% CI 1.16-4.26]; p= 0.015) and piecemeal endoscopic resection (OR 2.76 [95% CI 1.56-4.87]; p= 0.0005). Limitations of the study were: potential expertise bias, no data on eligible and potentially resectable excluded lesions, high percentage of lesions <20. mm, follow-up limited to 1 year. Conclusion: In this registry study the endoscopic resection of colorectal lesions was safe and achieved high rates of long-term endoscopic clearance.

KW - Adverse events

KW - Colorectal neoplasia

KW - Endoscopic resection

KW - Mucosectomy

KW - Outcomes

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U2 - 10.1016/j.dld.2013.09.019

DO - 10.1016/j.dld.2013.09.019

M3 - Article

VL - 46

SP - 146

EP - 151

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 2

ER -