Endoscopic stenting for colorectal cancer obstruction as a bridge-to-surgery strategy

Rosa Lovero, Giuseppe Losurdo, Rosa Federica La Fortezza, Fulvio Spirito, Alfredo Di Leo, Angelo Andriulli, Marco Gentile

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Acute obstructive colorectal cancer requires prompt decompression commonly by emergency surgery (ES). However, self-expanding metal stents (SEMS) have been increasingly used as a bridge-to-surgery (BTS) strategy. Materials and methods: In an 8-year period, consecutive patients with acute left-sided colonic obstruction, due to locally advanced colorectal cancer, underwent ES or SEMS implantation. We evaluated technical/clinical success of SEMS, adverse events, and overall (OS) and disease-free survival (DFS) of the two therapeutic options. Results: Forty-five patients underwent ES (n = 23) or SEMS (n = 22). The two groups were comparable for sex, age, ASA score and cancer site/stage. Technical and clinical successes of SEMS were 100% and 72.7%, respectively. Clinical success correlated with neutrophil-lymphocyte ratio (NLR) at baseline (OR = 0.65, 95% CI 0.43-0.98, P =.04). SEMS allowed primary anastomosis in the 45.5% of cases (0% in ES). SEMS implantation allowed a higher rate of surgery carried out by a laparoscopic approach: 36.4% vs 13.0% in ES. Performance of a definitive stoma and complications were similar. Median OS (34 in SEMS; 45 in ES, P =.33) and DFS (36 in SEMS; 35 in ES, P =.35) did not differ between the two groups. At univariate analysis, DFS was positively associated with primary anastomosis (HR = 2.44, 95% CI 1.4-16.6, P =.04) and laparoscopic surgery (HR = 8.33, 95% CI 1.08-50, P =.04), and inversely associated with a NLR > 3.6 (HR = 0.59, 95% CI 0.16-0.92, P =.03). At multivariate analysis, no feature retained an independent predictive power. Conclusion: SEMS is an effective and safe procedure, equivalent to emergency surgery in terms of complications, OS and DFS, providing the chance of a primary anastomosis in the majority of patients.

Original languageEnglish
Article numbere13252
JournalEuropean Journal of Clinical Investigation
Volume50
Issue number8
DOIs
Publication statusPublished - Aug 1 2020

Keywords

  • bridge to surgery
  • colorectal cancer
  • complications
  • SEMS
  • survival

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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