Endoscopic submucosal dissection of early gastric neoplastic lesions: A western series

Alessandro Repici, Angelo Zullo, Cesare Hassan, Paola Spaggiari, Giuseppe Strangio, Eva Vitetta, Elisa Ferrara, Alberto Malesci

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: Endoscopic submucosal dissection (ESD) has been found to be effective and safe for endoscopic removal of early gastric neoplasia in large Asian series. However, few data are available on the use of ESD in western countries. We assessed the efficacy of ESD performed in patients with early gastric neoplastic lesions. METHODS: We analyzed prospectively collected data of consecutive patients who underwent the ESD procedure for gastric neoplasia at a single Italian center. Procedure-related outcomes, including complete histological resection rate (i.e. R0 resection), immediate and late complication rate, procedure-related mortality, and follow-up were evaluated. RESULTS: Forty-two patients underwent gastric ESD. The en-bloc removal of lesions was successful in all cases, whereas R0 was achieved in 39 (92.8%) patients. A bleeding episode was observed in three (7.1%) patients, which was successfully managed by endoclip positioning. No perforations and procedure-related deaths were observed. The median follow-up period was 19 months (range: 9-53). A small residue of adenomatous lesion and a recurrent dysplastic lesion were removed by endoscopic mucosal resection in two (5%) patients. CONCLUSION: Our data are comparable with those of larger Asian series. Use of ESD for removal of gastric neoplastic lesions should be implemented in western countries.

Original languageEnglish
Pages (from-to)1261-1264
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • complications
  • early neoplastic lesions
  • endoscopic submucosal dissection
  • stomach

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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