Endoscopic treatment of biliary complications after liver transplantation

Ilaria Tarantino, Luca Barresi, Ioannis Petridis, Riccardo Volpes, Mario Traina, Bruno Gridelli

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate the of efficacy endoscopic treatment in patients who undergo OLTx or LRLTx and develop biliary complications. Methods: This is a prospective, observational study of patients who developed biliary complications, after OLTx and LRLTx, with duct-to-duct anastomosis Performed between June 2003 and June 2007. Endoscopic Retrograde Cholangiopancreatography (ERCP) was considered unsuccessful when there was evidence of continuous bile leakage despite endoscopic stent placement, or persistence of stenosis after 1 year, despite multiple dilatation and stent placement. When the ERCP failed, a percutaneous trans-hepatic approach (PTC) or surgery was adopted. Results: From June 2003 to June 2007, 261 adult patients were transplanted in our institute, 68 from living donors and 193 from cadaveric donors. In the OLTx group the rate of complications was 37.3%, while in the LRLTx group was 64.7%. The rate of ERCP failure was 19.4% in the OLTx group and 38.6% in LRLTx group. In OLTx group, 1 patient was retransplanted and 8 patients died. In the LRLTx group, 2 patients underwent OLTx and 8 patients died. The follow-up was 23.3 " 13.13 mo and 21.02 " 14.10 mo, respectively. Conclusion: Although ERCP is quite an effective mode of managing post-transplant bile duct complications, a significant number of patients need other types of approach. Further prospective studies are necessary in order to establish whether other endoscopic protocols or new devices, could improve the current results.

Original languageEnglish
Pages (from-to)4185-4189
Number of pages5
JournalWorld Journal of Gastroenterology
Volume14
Issue number26
DOIs
Publication statusPublished - 2008

Keywords

  • Benign stenosis
  • Biliary complication
  • Biliary leak
  • Endoscopic retrograde cholangiopancreatography
  • Liver transplant

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint

Dive into the research topics of 'Endoscopic treatment of biliary complications after liver transplantation'. Together they form a unique fingerprint.

Cite this