Endothelial and platelet function in children with previous kawasaki disease

Marianna Laurito, Alessandra Stazi, Angelica B. Delogu, Maria Milo, Irma Battipaglia, Giancarla Scalone, Fabio Infusino, Angelo Villano, Giulio Russo, Rossella Iannotta, Annalisa Saracino, Rossella Parrinello, Stefano Figliozzi, Alfonso Sestito, Costantino Romagnoli, Gaetano A. Lanza, Filippo Crea

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P =.01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P

Original languageEnglish
Pages (from-to)716-722
Number of pages7
JournalAngiology
Volume65
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • carotid intima-medial thickness
  • endothelial function
  • Kawasaki disease
  • platelet function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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