Endothelial cell heterogeneity and organ specificity

Domenico Ribatti, Beatrice Nico, Angelo Vacca, Luisa Roncali, Franco Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelial cells consist of a heterogeneous population covering the entire inner surface of blood vessels. This review will focus on the factors influencing this heterogeneity including: (1) morphological and functional differences between large and small vessels and between cells derived from various microvascular endothelial beds; (2) the microenvironment and extracellular matrix modulating the phenotype; (3) different response to growth factors; (4) organ specificity reflecting the cumulative expression of post-translation modifications and also the expression of unique genes under the control of organ-specific regulatory elements; and (5) pathological conditions, such as tumor growth, which is accompanied by the development of a characteristic tumor vasculature and tumors formed by endothelial cells.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalJournal of Hematotherapy and Stem Cell Research
Volume11
Issue number1
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Hematology
  • Immunology

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