TY - JOUR
T1 - Endothelial damage during myocardial preservation and storage
AU - Parolari, Alessandro
AU - Rubini, Patrizia
AU - Cannata, Aldo
AU - Bonati, Luigi
AU - Alamanni, Francesco
AU - Tremoli, Elena
AU - Biglioli, Paolo
PY - 2002
Y1 - 2002
N2 - Preservation and storage techniques represent two major issues in routine cardiac surgery and heart transplantation. Historically, these methods were conceived to prevent ischemic injury to myocardium after cardiac arrest during heart operations. Evidence shows that endothelium plays a critical role in the maintenance of normal heart function after cardiac operation, mainly by controlling he coronary circulation. Methods for preservation and storage, developed initially to protect cardiomyocyte function, may be deleterious for vascular endothelium and compromise myocardial protection. In this review article the present knowledge about endothelial injury secondary to preservation and storage techniques is discussed.
AB - Preservation and storage techniques represent two major issues in routine cardiac surgery and heart transplantation. Historically, these methods were conceived to prevent ischemic injury to myocardium after cardiac arrest during heart operations. Evidence shows that endothelium plays a critical role in the maintenance of normal heart function after cardiac operation, mainly by controlling he coronary circulation. Methods for preservation and storage, developed initially to protect cardiomyocyte function, may be deleterious for vascular endothelium and compromise myocardial protection. In this review article the present knowledge about endothelial injury secondary to preservation and storage techniques is discussed.
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U2 - 10.1016/S0003-4975(01)03029-6
DO - 10.1016/S0003-4975(01)03029-6
M3 - Article
C2 - 11845908
AN - SCOPUS:0036159668
VL - 73
SP - 682
EP - 690
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 2
ER -