Endothelial dysfunction as assessed by flow-mediated dilation in patients with cardiac syndrome X: Role of inflammation

Paolo Tondi, A. Santoliquido, A. Di Giorgio, A. Sestito, G. A. Sgueglia, R. Flore, G. Careri, G. Pinnacchio, G. A. Lanza, F. Crea

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Endothelial dysfunction, reduced coronary flow reserve and increased markers of inflammation are detectable in cardiac syndrome X (CSX). In this study we investigated the relation between inflammation and systemic endothelial function in CSX patients. Methods: We studied 42 CSX patients (55±6 years, 14 men) and 20 healthy subjects (52±7 years, 9 men). Systemic endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery after 5-minute of forearm cuff inflation. Serum C-reactive protein (CRP) was measured by a high-sensitivity method. Results: FMD was significantly lower in CSX patients compared to controls (4.8±4.4 vs. 13.7±4%, p

Original languageEnglish
Pages (from-to)1074-1077
Number of pages4
JournalEuropean Review for Medical and Pharmacological Sciences
Volume15
Issue number9
Publication statusPublished - Sep 2011

Keywords

  • Endothelial dysfunction
  • Inflammation
  • Syndrome X

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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