Endothelial dysfunction evaluated by flow mediated dilation is strongly associated to metabolic syndrome in the elderly

Angela De Matthaeis, Antonio Greco, Gaetano Serviddio, Giovanna Stramaglia, Gianluigi Vendemiale

Research output: Contribution to journalArticle


This study was carried out to assess whether endothelial dysfunction, evaluated by flow-mediated dilation (FMD), is related to the occurrence of the Metabolic Syndrome (MetS) in old age. Eighty patients (25 men and 55 women), mean age 74.1±7.4 years (range 65-99 yrs) were studied. Information on all subjects, medical history and regular medications was obtained. Subjects underwent a clinical examination and laboratory tests. The presence of MetS was evaluated according to the revised NCEP-ATP III criteria. An ultrasound vascular examination (US) of the carotid and brachial arteries was performed in all patients. Intima-media thickness (IMT), presence of plaques (PL), endothelium-dependent (EDV) and -independent vasodilation (EIDV) were also evaluated. Patients were divided into two groups according to the presence/absence of MetS. Significant differences were found between MetS and non MetS patients in: EDV (p

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalAging clinical and experimental research
Issue number4
Publication statusPublished - Aug 2010



  • Elderly
  • Endothelial dysfunction
  • Flow mediated dilation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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