Endothelial Dysfunction in Carotid Elongation

Claudio Baracchini, Filippo Farina, Simone Tonello, Valentina Citton, Giorgio Meneghetti, Enzo Ballotta, Renzo Manara

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Internal carotid artery (ICA) elongation (coiling and kinking) has been suggested as a risk factor for carotid dissection. Since vasomotion is known to be impaired in spontaneous cervical vessel dissection, we investigated whether endothelial-dependent vasodilation in subjects with carotid coiling and kinking is compromised. Methods: We undertook a case-control study using high-resolution ultrasound and measured flow-mediated dilation (FMD) of the brachial artery in 80 subjects with carotid elongation and in 80 age- and sex-matched healthy controls (HC). The hemodynamic impact of carotid elongation was taken into consideration subdividing mild/moderate kinking from severe kinking according to a peak systolic blood flow velocity >150 cm/s. Results: FMD did not differ among subjects with coiling (14.51 ± 7.86%), mild/moderate kinking (14.38 ± 9.58%) and HC (15.53 ± 8.48%), while subjects with a severe kinking had a significantly lower FMD (8.38 ± 3.26). Conclusions: Among subjects with carotid elongation, those with severe kinking have an impaired endothelial-dependent vasodilation and might be prone to carotid dissection.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalJournal of Neuroimaging
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Carotid dissection
  • Carotid elongation
  • Endothelial dysfunction
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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    Baracchini, C., Farina, F., Tonello, S., Citton, V., Meneghetti, G., Ballotta, E., & Manara, R. (2013). Endothelial Dysfunction in Carotid Elongation. Journal of Neuroimaging, 23(1), 18-20. https://doi.org/10.1111/j.1552-6569.2011.00653.x