Endothelial Dysfunction in Carotid Elongation

Claudio Baracchini, Filippo Farina, Simone Tonello, Valentina Citton, Giorgio Meneghetti, Enzo Ballotta, Renzo Manara

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Internal carotid artery (ICA) elongation (coiling and kinking) has been suggested as a risk factor for carotid dissection. Since vasomotion is known to be impaired in spontaneous cervical vessel dissection, we investigated whether endothelial-dependent vasodilation in subjects with carotid coiling and kinking is compromised. Methods: We undertook a case-control study using high-resolution ultrasound and measured flow-mediated dilation (FMD) of the brachial artery in 80 subjects with carotid elongation and in 80 age- and sex-matched healthy controls (HC). The hemodynamic impact of carotid elongation was taken into consideration subdividing mild/moderate kinking from severe kinking according to a peak systolic blood flow velocity >150 cm/s. Results: FMD did not differ among subjects with coiling (14.51 ± 7.86%), mild/moderate kinking (14.38 ± 9.58%) and HC (15.53 ± 8.48%), while subjects with a severe kinking had a significantly lower FMD (8.38 ± 3.26). Conclusions: Among subjects with carotid elongation, those with severe kinking have an impaired endothelial-dependent vasodilation and might be prone to carotid dissection.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalJournal of Neuroimaging
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Dissection
Dilatation
Vasodilation
Brachial Artery
Blood Flow Velocity
Internal Carotid Artery
Case-Control Studies
Hemodynamics

Keywords

  • Carotid dissection
  • Carotid elongation
  • Endothelial dysfunction
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Baracchini, C., Farina, F., Tonello, S., Citton, V., Meneghetti, G., Ballotta, E., & Manara, R. (2013). Endothelial Dysfunction in Carotid Elongation. Journal of Neuroimaging, 23(1), 18-20. https://doi.org/10.1111/j.1552-6569.2011.00653.x

Endothelial Dysfunction in Carotid Elongation. / Baracchini, Claudio; Farina, Filippo; Tonello, Simone; Citton, Valentina; Meneghetti, Giorgio; Ballotta, Enzo; Manara, Renzo.

In: Journal of Neuroimaging, Vol. 23, No. 1, 01.2013, p. 18-20.

Research output: Contribution to journalArticle

Baracchini, C, Farina, F, Tonello, S, Citton, V, Meneghetti, G, Ballotta, E & Manara, R 2013, 'Endothelial Dysfunction in Carotid Elongation', Journal of Neuroimaging, vol. 23, no. 1, pp. 18-20. https://doi.org/10.1111/j.1552-6569.2011.00653.x
Baracchini C, Farina F, Tonello S, Citton V, Meneghetti G, Ballotta E et al. Endothelial Dysfunction in Carotid Elongation. Journal of Neuroimaging. 2013 Jan;23(1):18-20. https://doi.org/10.1111/j.1552-6569.2011.00653.x
Baracchini, Claudio ; Farina, Filippo ; Tonello, Simone ; Citton, Valentina ; Meneghetti, Giorgio ; Ballotta, Enzo ; Manara, Renzo. / Endothelial Dysfunction in Carotid Elongation. In: Journal of Neuroimaging. 2013 ; Vol. 23, No. 1. pp. 18-20.
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