Abstract
PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P
| Original language | English |
|---|---|
| Journal | American Journal of Medicine |
| Volume | 119 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2006 |
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Keywords
- Adiponectin
- Endothelium
- Insulin
- Leptin
- PCOS
ASJC Scopus subject areas
- Nursing(all)
Cite this
Endothelial dysfunction in PCOS : Role of obesity and adipose hormones. / Carmina, E.; Orio, F.; Palomba, S.; Longo, R. A.; Cascella, T.; Colao, A.; Lombardi, G.; Rini, G. B.; Lobo, Rogerio A.
In: American Journal of Medicine, Vol. 119, No. 4, 04.2006.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endothelial dysfunction in PCOS
T2 - Role of obesity and adipose hormones
AU - Carmina, E.
AU - Orio, F.
AU - Palomba, S.
AU - Longo, R. A.
AU - Cascella, T.
AU - Colao, A.
AU - Lombardi, G.
AU - Rini, G. B.
AU - Lobo, Rogerio A.
PY - 2006/4
Y1 - 2006/4
N2 - PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P
AB - PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P
KW - Adiponectin
KW - Endothelium
KW - Insulin
KW - Leptin
KW - PCOS
UR - http://www.scopus.com/inward/record.url?scp=33645237483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645237483&partnerID=8YFLogxK
U2 - 10.1016/j.amjmed.2005.10.059
DO - 10.1016/j.amjmed.2005.10.059
M3 - Article
C2 - 16564785
AN - SCOPUS:33645237483
VL - 119
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 4
ER -