Endothelial dysfunction in PCOS: Role of obesity and adipose hormones

E. Carmina; F. Orio; S. Palomba; R. A. Longo; T. Cascella; A. Colao; G. Lombardi; G. B. Rini; Rogerio A. Lobo

doi:10.1016/j.amjmed.2005.10.059

Endothelial dysfunction in PCOS: Role of obesity and adipose hormones

E. Carmina, F. Orio, S. Palomba, R. A. Longo, T. Cascella, A. Colao, G. Lombardi, G. B. Rini, Rogerio A. Lobo

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P

Original language	English
Journal	American Journal of Medicine
Volume	119
Issue number	4
DOIs	https://doi.org/10.1016/j.amjmed.2005.10.059
Publication status	Published - Apr 2006

Keywords

Adiponectin
Endothelium
Insulin
Leptin
PCOS

ASJC Scopus subject areas

Nursing(all)

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10.1016/j.amjmed.2005.10.059

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title = "Endothelial dysfunction in PCOS: Role of obesity and adipose hormones",

abstract = "PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P ",

keywords = "Adiponectin, Endothelium, Insulin, Leptin, PCOS",

author = "E. Carmina and F. Orio and S. Palomba and Longo, {R. A.} and T. Cascella and A. Colao and G. Lombardi and Rini, {G. B.} and Lobo, {Rogerio A.}",

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T2 - Role of obesity and adipose hormones

AU - Carmina, E.

AU - Orio, F.

AU - Palomba, S.

AU - Longo, R. A.

AU - Cascella, T.

AU - Colao, A.

AU - Lombardi, G.

AU - Rini, G. B.

AU - Lobo, Rogerio A.

PY - 2006/4

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N2 - PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P

AB - PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P

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KW - Endothelium

KW - Insulin

KW - Leptin

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