Endothelial dysfunction in PCOS: Role of obesity and adipose hormones

E. Carmina, F. Orio, S. Palomba, R. A. Longo, T. Cascella, A. Colao, G. Lombardi, G. B. Rini, Rogerio A. Lobo

Research output: Contribution to journalArticlepeer-review


PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 ± 1 years; body mass index [BMI]: 28.7 ± 0.8) and 50 matched ovulatory controls (age: 25.1 ± 0.7 years; BMI: 28.5 ± 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, adiponectin and resistin were measured. RESULTS: PCOS, IMT was increased (P

Original languageEnglish
JournalAmerican Journal of Medicine
Issue number4
Publication statusPublished - Apr 2006


  • Adiponectin
  • Endothelium
  • Insulin
  • Leptin
  • PCOS

ASJC Scopus subject areas

  • Nursing(all)


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