Endothelial Progenitor Cell CD34+ and CD133+ Concentrations and Soluble HLA-G Concentrations During Pregnancy and in Cord Blood in Undifferentiated Connective Tissue Diseases Compared to Controls

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Abstract

The objective of this study is to evaluate endothelial progenitor cells (EPCs) CD34+ CD133 and CD34+ CD133+ and soluble HLA-G (sHLA-G) concentrations among undifferentiated connective tissue disease (UCTD) subjects, compared to controls, during pregnancy and in cord blood. This is a case-control study including 29 controls and 29 UCTDs. CD34+ CD133, CD34+ CD133+, and sHLA-G concentrations were detected in maternal plasma and in cord blood. This study was approved by the Medical-Ethical Committee of our Institution (Current Research Project N. 901-rcr2017i-23 of IRCCS Foundation Policlinico San Matteo of Pavia). Circulating CD34+ CD133 and CD34+ CD133+ counts and sHLA-G (soluble human leucocyte antigen G) concentrations in maternal peripherical blood were higher in UCTD compared to those in controls in first and third trimester of pregnancy and at delivery (p < 0.001). Maternal CD34+ CD133 and CD34+ CD133+ counts were strongly and significantly correlated in UCTD (Spearman’s rho = 0.79, p < 0.0001) but not in controls (Spearman’s rho = 0.10, p = 0.35). Cord blood CD34+ CD133 and CD34+ CD133+ median counts and median sHLA-G concentrations were higher among UCTD subjects than in controls (p < 0.001). Cord blood CD34+ and CD133+ counts were inversely and significantly correlated with sHLA-G concentrations among UCTDs, but not in controls. Early UCTD is characterized by increased EPC levels in maternal plasma and in cord blood and higher levels of sHLA-G, compared to controls. Data suggest that fetoplacental unit plays an independent role in the EPC response to a systemic autoimmune disease.

Original languageEnglish
Pages (from-to)1382-1389
Number of pages8
JournalReproductive Sciences
Volume28
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • Circulating endothelial progenitor cells
  • HLA-G
  • Pregnancy
  • Undifferentiated connective tissue diseases

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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