Endothelial progenitor cells, bronchopulmonary dysplasia and other short-term outcomes of extremely preterm birth

Giulia Paviotti, Gian Paolo Fadini, Elisa Boscaro, Carlo Agostini, Angelo Avogaro, Lino Chiandetti, Eugenio Baraldi, Marco Filippone

Research output: Contribution to journalArticle

Abstract

Aim: To evaluate the impact of endothelial progenitor cells (EPCs), a subset of committed circulatory stem cells, on the development of bronchopulmonary dysplasia (BPD) and other short term outcomes in a cohort of extremely premature newborns. Methods: Progenitor cells were quantified by flow cytometry at birth in 36 neonates born +KDR+ EPCs: 81(34-41) vs 80(56-110), p=0.7] and were not correlated with the duration of mechanical ventilation or O2-dependence, nor with the need of surfactant replacement. Infants with a hemodynamically significant patent ductus arteriosus (PDA) (n=22) had significantly lower EPC levels at birth than those with no PDA (n=11) [CD34+KDR+ cells: 47(34-92) vs 142(84.5-221), p=0.008]. Data from the 18 infants studied both at birth and at 36 postmenstrual weeks showed that, while CPCs sharply decline over time, levels of all EPCs phenotypes are preserved after delivery. Conclusions: Levels of EPCs at birth did not affect the risk of developing BPD in our group of extremely premature neonates. However, the association between low EPC counts at birth and PDA may be clinically relevant, and deserves further studies.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalEarly Human Development
Volume87
Issue number7
DOIs
Publication statusPublished - Jul 2011

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Keywords

  • Bronchopulmonary dysplasia
  • Endothelial progenitor cells
  • Patent ductus arteriosus
  • Prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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