Abstract
Conclusions: Endothelial progenitor cells (EPCs) are a unique subtype of circulating cells with properties similar to those of embryonal angioblasts. They have the potential to proliferate and to differentiate into mature endothelial cells. EPCs are reduced in patients with vascular risk factors due to a decreased mobilization, an increased consumption at the site of damage or a reduced half-life. The results of this study confirm the existence of an endothelial dysfunction in patients with sudden sensorineural hearing loss (SSHL) and support the vascular involvement in the pathogenesis of the disease. Objective: The aim of this study was to evaluate the concentration of EPCs in patients affected by SSHL. Methods: Twenty-one patients affected by SSHL were evaluated. The number of EPCs was analyzed by flow cytometry analysis of peripheral blood CD34+KDR+CD133+ cells. Results: Circulating levels of EPCs were significantly lower in SSHL patients compared with controls. In particular, CD34+KDR+ cells and CD34+CD133+KDR+ cells were significantly reduced (p <0.05).
| Original language | English |
|---|---|
| Pages (from-to) | 347-350 |
| Number of pages | 4 |
| Journal | Acta Oto-Laryngologica |
| Volume | 131 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2011 |
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Keywords
- Endothelial dysfunction
- flow cytometry
- vascular risk factors
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Endothelial progenitor cells in sudden sensorineural hearing loss. / Quaranta, Nicola; Ramunni, Alfonso; De Luca, Concetta; Brescia, Paola; Dambra, Porzia; De Tullio, Giacomina; Vacca, Angelo; Quaranta, Antonio.
In: Acta Oto-Laryngologica, Vol. 131, No. 4, 04.2011, p. 347-350.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endothelial progenitor cells in sudden sensorineural hearing loss
AU - Quaranta, Nicola
AU - Ramunni, Alfonso
AU - De Luca, Concetta
AU - Brescia, Paola
AU - Dambra, Porzia
AU - De Tullio, Giacomina
AU - Vacca, Angelo
AU - Quaranta, Antonio
PY - 2011/4
Y1 - 2011/4
N2 - Conclusions: Endothelial progenitor cells (EPCs) are a unique subtype of circulating cells with properties similar to those of embryonal angioblasts. They have the potential to proliferate and to differentiate into mature endothelial cells. EPCs are reduced in patients with vascular risk factors due to a decreased mobilization, an increased consumption at the site of damage or a reduced half-life. The results of this study confirm the existence of an endothelial dysfunction in patients with sudden sensorineural hearing loss (SSHL) and support the vascular involvement in the pathogenesis of the disease. Objective: The aim of this study was to evaluate the concentration of EPCs in patients affected by SSHL. Methods: Twenty-one patients affected by SSHL were evaluated. The number of EPCs was analyzed by flow cytometry analysis of peripheral blood CD34+KDR+CD133+ cells. Results: Circulating levels of EPCs were significantly lower in SSHL patients compared with controls. In particular, CD34+KDR+ cells and CD34+CD133+KDR+ cells were significantly reduced (p <0.05).
AB - Conclusions: Endothelial progenitor cells (EPCs) are a unique subtype of circulating cells with properties similar to those of embryonal angioblasts. They have the potential to proliferate and to differentiate into mature endothelial cells. EPCs are reduced in patients with vascular risk factors due to a decreased mobilization, an increased consumption at the site of damage or a reduced half-life. The results of this study confirm the existence of an endothelial dysfunction in patients with sudden sensorineural hearing loss (SSHL) and support the vascular involvement in the pathogenesis of the disease. Objective: The aim of this study was to evaluate the concentration of EPCs in patients affected by SSHL. Methods: Twenty-one patients affected by SSHL were evaluated. The number of EPCs was analyzed by flow cytometry analysis of peripheral blood CD34+KDR+CD133+ cells. Results: Circulating levels of EPCs were significantly lower in SSHL patients compared with controls. In particular, CD34+KDR+ cells and CD34+CD133+KDR+ cells were significantly reduced (p <0.05).
KW - Endothelial dysfunction
KW - flow cytometry
KW - vascular risk factors
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U2 - 10.3109/00016489.2010.536990
DO - 10.3109/00016489.2010.536990
M3 - Article
VL - 131
SP - 347
EP - 350
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 4
ER -