Endothelial tissue factor induction by T lymphocytes in systemic sclerosis

S. Della Bella; L. Mussoni; M. Molteni; S. Colli; C. Zulian; M. Camera; E. Tremoli; R. Scorza

doi:10.1007/s100670050049

Endothelial tissue factor induction by T lymphocytes in systemic sclerosis

S. Della Bella, L. Mussoni, M. Molteni, S. Colli, C. Zulian, M. Camera, E. Tremoli, R. Scorza

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the ability of circulating T lymphocytes obtained from patients with systemic sclerosis (SSc) to induce the expression of tissue factor (TF) by human umbilical vein endothelial cells (HUVECs), and compared the results with those obtained from healthy controls. Nine patients with SSc and 10 sex- and age-matched healthy subjects were studied. Peripheral T lymphocytes obtained from SSc patients induced TF activity from HUVECs in a dose-dependent manner. A significant induction of endothelial TF was observed when 2 x 10⁶ lymphocytes per well (TF values, mean ± SD: 0.34 ± 0.21U/μg of cell protein vs 0.04 ± 0.03; n = 9, p = 0.001) or 1 x 10⁶ lymphocytes per well (0.13 ± 0.06 vs 0.04 ± 0.04; n = 8, p

Original language	English
Pages (from-to)	38-41
Number of pages	4
Journal	Clinical Rheumatology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s100670050049
Publication status	Published - 1999

Keywords

Endothelial cells
Lymphocytes
Systemic sclerosis
Tissue factor

ASJC Scopus subject areas

Rheumatology
Immunology

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10.1007/s100670050049

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title = "Endothelial tissue factor induction by T lymphocytes in systemic sclerosis",

abstract = "We evaluated the ability of circulating T lymphocytes obtained from patients with systemic sclerosis (SSc) to induce the expression of tissue factor (TF) by human umbilical vein endothelial cells (HUVECs), and compared the results with those obtained from healthy controls. Nine patients with SSc and 10 sex- and age-matched healthy subjects were studied. Peripheral T lymphocytes obtained from SSc patients induced TF activity from HUVECs in a dose-dependent manner. A significant induction of endothelial TF was observed when 2 x 106 lymphocytes per well (TF values, mean ± SD: 0.34 ± 0.21U/μg of cell protein vs 0.04 ± 0.03; n = 9, p = 0.001) or 1 x 106 lymphocytes per well (0.13 ± 0.06 vs 0.04 ± 0.04; n = 8, p",

keywords = "Endothelial cells, Lymphocytes, Systemic sclerosis, Tissue factor",

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T1 - Endothelial tissue factor induction by T lymphocytes in systemic sclerosis

AU - Della Bella, S.

AU - Mussoni, L.

AU - Molteni, M.

AU - Colli, S.

AU - Zulian, C.

AU - Camera, M.

AU - Tremoli, E.

AU - Scorza, R.

PY - 1999

Y1 - 1999

N2 - We evaluated the ability of circulating T lymphocytes obtained from patients with systemic sclerosis (SSc) to induce the expression of tissue factor (TF) by human umbilical vein endothelial cells (HUVECs), and compared the results with those obtained from healthy controls. Nine patients with SSc and 10 sex- and age-matched healthy subjects were studied. Peripheral T lymphocytes obtained from SSc patients induced TF activity from HUVECs in a dose-dependent manner. A significant induction of endothelial TF was observed when 2 x 106 lymphocytes per well (TF values, mean ± SD: 0.34 ± 0.21U/μg of cell protein vs 0.04 ± 0.03; n = 9, p = 0.001) or 1 x 106 lymphocytes per well (0.13 ± 0.06 vs 0.04 ± 0.04; n = 8, p

AB - We evaluated the ability of circulating T lymphocytes obtained from patients with systemic sclerosis (SSc) to induce the expression of tissue factor (TF) by human umbilical vein endothelial cells (HUVECs), and compared the results with those obtained from healthy controls. Nine patients with SSc and 10 sex- and age-matched healthy subjects were studied. Peripheral T lymphocytes obtained from SSc patients induced TF activity from HUVECs in a dose-dependent manner. A significant induction of endothelial TF was observed when 2 x 106 lymphocytes per well (TF values, mean ± SD: 0.34 ± 0.21U/μg of cell protein vs 0.04 ± 0.03; n = 9, p = 0.001) or 1 x 106 lymphocytes per well (0.13 ± 0.06 vs 0.04 ± 0.04; n = 8, p

KW - Endothelial cells

KW - Lymphocytes

KW - Systemic sclerosis

KW - Tissue factor

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