Endothelial tissue factor induction by T lymphocytes in systemic sclerosis

S. Della Bella, L. Mussoni, M. Molteni, S. Colli, C. Zulian, M. Camera, E. Tremoli, R. Scorza

Research output: Contribution to journalArticle

Abstract

We evaluated the ability of circulating T lymphocytes obtained from patients with systemic sclerosis (SSc) to induce the expression of tissue factor (TF) by human umbilical vein endothelial cells (HUVECs), and compared the results with those obtained from healthy controls. Nine patients with SSc and 10 sex- and age-matched healthy subjects were studied. Peripheral T lymphocytes obtained from SSc patients induced TF activity from HUVECs in a dose-dependent manner. A significant induction of endothelial TF was observed when 2 x 106 lymphocytes per well (TF values, mean ± SD: 0.34 ± 0.21U/μg of cell protein vs 0.04 ± 0.03; n = 9, p = 0.001) or 1 x 106 lymphocytes per well (0.13 ± 0.06 vs 0.04 ± 0.04; n = 8, p

Original languageEnglish
Pages (from-to)38-41
Number of pages4
JournalClinical Rheumatology
Volume18
Issue number1
DOIs
Publication statusPublished - 1999

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Keywords

  • Endothelial cells
  • Lymphocytes
  • Systemic sclerosis
  • Tissue factor

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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