Abstract
We evaluated the ability of circulating T lymphocytes obtained from patients with systemic sclerosis (SSc) to induce the expression of tissue factor (TF) by human umbilical vein endothelial cells (HUVECs), and compared the results with those obtained from healthy controls. Nine patients with SSc and 10 sex- and age-matched healthy subjects were studied. Peripheral T lymphocytes obtained from SSc patients induced TF activity from HUVECs in a dose-dependent manner. A significant induction of endothelial TF was observed when 2 x 106 lymphocytes per well (TF values, mean ± SD: 0.34 ± 0.21U/μg of cell protein vs 0.04 ± 0.03; n = 9, p = 0.001) or 1 x 106 lymphocytes per well (0.13 ± 0.06 vs 0.04 ± 0.04; n = 8, p
Original language | English |
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Pages (from-to) | 38-41 |
Number of pages | 4 |
Journal | Clinical Rheumatology |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1999 |
Keywords
- Endothelial cells
- Lymphocytes
- Systemic sclerosis
- Tissue factor
ASJC Scopus subject areas
- Rheumatology
- Immunology