Endothelin-1 and brain natriuretic peptide plasma levels decrease after aortic surgery

Giuseppe M. Raffa, Veronica Jackson, Jan Liska, Maria J. Eriksson, Kenneth Caidahl, Per Eriksson, Anders Franco-Cereceda

Research output: Contribution to journalArticlepeer-review


Background and aim of the study: Endothelin-1 (ET-1) and B-type natriuretic peptide (BNP) have been reported to be involved in numerous cardiovascular diseases. The study aim was to monitor the circulating plasma levels of these peptides in patients affected by aortic disease, and to identify any changes in such levels after surgical treatment. Methods: A total of 81 patients (52 males, 29 females; mean age 64 ± 11 years) with aortic disease underwent surgery. The conditions included aortic valve stenosis (n = 36), aortic valve regurgitation (n = 11), ascending aortic aneurysm (n = 6), and combined ascending aortic aneurysm and valvulopathy (n = 28). Circulating plasma levels of ET-1 and BNP were measured in all patients before and at 12 months after surgery. Results: Compared to the preoperative situation, significant decreases were found postoperatively in plasma levels of ET-1 (4.2 ± 0.1 versus 3.1 ± 0.1 pM; p

Original languageEnglish
Pages (from-to)724-730
Number of pages7
JournalJournal of Heart Valve Disease
Issue number6
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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