TY - JOUR
T1 - Endothelin-1 circulating levels increase in patients with orthotopic heart transplantation and in chronic therapy with cyclosporine
AU - Letizia, C.
AU - De Biase, L.
AU - Caliumi, C.
AU - Verrelli, C.
AU - Semeraro, R.
AU - Subioli, S.
AU - Cerci, S.
AU - D'Erasmo, E.
PY - 2001/2
Y1 - 2001/2
N2 - Background. The aim of the study was to investigate the behaviour of plasma levels of endothelin-1 (ET-1), an endothelial peptide with vasoconstrictive and proliferative actions, in patients with cardiac transplantation and in chronic treatment with cyclosporine A, some of whom became hypertensive after cardiac transplantation. Methods. We studied: 1) 18 consecutive patients (15 M, 3 F; mean age 53±7 yrs) who underwent cardiac transplantation about six months ago at least (range 6-108 months); 2) 15 patients with essential arterial hypertension (10 M, 5 F; mean age 42±15 yrs) without organ damage; 3) 21 normal subjects (15 M, 6 F; mean age 31±12 yrs). Plasma levels of ET-1 (RIA), haemodynamic and functional renal parameters were determined in all groups and plasma levels of cyclosporine were measured in patients with cardiac transplantation. Results. ET-1 was higher in patients with cardiac transplantation than in the other two groups (p0.05). A statistical difference was found between circulating ET-1 in hypertensive transplanted patients (61%) and those in normotensive transplanted patients. In heart transplanted patients a positive and significative correlation was found between plasma levels of ET-1 and systolic (r=0.792; p
AB - Background. The aim of the study was to investigate the behaviour of plasma levels of endothelin-1 (ET-1), an endothelial peptide with vasoconstrictive and proliferative actions, in patients with cardiac transplantation and in chronic treatment with cyclosporine A, some of whom became hypertensive after cardiac transplantation. Methods. We studied: 1) 18 consecutive patients (15 M, 3 F; mean age 53±7 yrs) who underwent cardiac transplantation about six months ago at least (range 6-108 months); 2) 15 patients with essential arterial hypertension (10 M, 5 F; mean age 42±15 yrs) without organ damage; 3) 21 normal subjects (15 M, 6 F; mean age 31±12 yrs). Plasma levels of ET-1 (RIA), haemodynamic and functional renal parameters were determined in all groups and plasma levels of cyclosporine were measured in patients with cardiac transplantation. Results. ET-1 was higher in patients with cardiac transplantation than in the other two groups (p0.05). A statistical difference was found between circulating ET-1 in hypertensive transplanted patients (61%) and those in normotensive transplanted patients. In heart transplanted patients a positive and significative correlation was found between plasma levels of ET-1 and systolic (r=0.792; p
KW - Endothelin-1
KW - Heart transplantation
KW - Hypertension
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M3 - Article
C2 - 11360881
AN - SCOPUS:0035048943
VL - 49
SP - 15
EP - 22
JO - Minerva Cardioangiologica
JF - Minerva Cardioangiologica
SN - 0026-4725
IS - 1
ER -